Lupidi Marco, Cerquaglia Alessio, Chhablani Jay, Fiore Tito, Singh Sumit Randhir, Cardillo Piccolino Felice, Corbucci Roberta, Coscas Florence, Coscas Gabriel, Cagini Carlo
1 Department of Biomedical and Surgical Sciences, Section of Ophthalmology, University of Perugia, S. Maria della Misericordia Hospital, Perugia, Italy.
2 Centre de l'Odéon, Paris, France.
Eur J Ophthalmol. 2018 Jul;28(4):349-357. doi: 10.1177/1120672118766807. Epub 2018 Apr 6.
Optical coherence tomography angiography is one of the biggest advances in ophthalmic imaging. It enables a depth-resolved assessment of the retinal and choroidal blood flow, far exceeding the levels of detail commonly obtained with dye angiographies. One of the first applications of optical coherence tomography angiography was in detecting the presence of choroidal neovascularization in age-related macular degeneration and establishing its position in relation to the retinal pigmented epithelium and Bruch's membrane, and thereby classifying the CNV as type 1, type 2, type 3, or mixed lesions. Optical coherence tomography angiograms, due to the longer wavelength used by optical coherence tomography, showed a more distinct choroidal neovascularization vascular pattern than fluorescein angiography, since there is less suffering from light scattering or is less obscured by overlying subretinal hemorrhages or exudation. Qualitative and quantitative assessments of optical coherence tomography angiography findings in exudative and nonexudative age-related macular degeneration have been largely investigated within the past 3 years both in clinical and experimental settings. This review constitutes an up-to-date of all the potential applications of optical coherence tomography angiography in age-related macular degeneration in order to better understand how to translate its theoretical usefulness into the current clinical practice.
光学相干断层扫描血管造影术是眼科成像领域最大的进展之一。它能够对视网膜和脉络膜血流进行深度分辨评估，其细节程度远超传统染料血管造影术。光学相干断层扫描血管造影术的首批应用之一是检测年龄相关性黄斑变性中脉络膜新生血管的存在，并确定其相对于视网膜色素上皮和布鲁赫膜的位置，从而将脉络膜新生血管分为1型、2型、3型或混合性病变。由于光学相干断层扫描使用的波长较长，光学相干断层扫描血管造影显示的脉络膜新生血管血管模式比荧光素血管造影更清晰，因为光散射较少，或较少被视网膜下出血或渗出物掩盖。在过去3年里，临床和实验环境中对渗出性和非渗出性年龄相关性黄斑变性的光学相干断层扫描血管造影结果进行了大量的定性和定量评估。这篇综述对光学相干断层扫描血管造影术在年龄相关性黄斑变性中的所有潜在应用进行了更新，以便更好地理解如何将其理论效用转化为当前的临床实践。
