Maloca Peter M, Feu-Basilio Silvia, Schottenhamml Julia, Valmaggia Philippe, Scholl Hendrik P N, Rosinés-Fonoll Josep, Marin-Martinez Sara, Inglin Nadja, Reich Michael, Lange Clemens, Egan Catherine, Zweifel Sandrine, Tufail Adnan, Spaide Richard F, Zarranz-Ventura Javier
Institute of Molecular and Clinical Ophthalmology Basel, 4031, Basel, Switzerland.
Department of Ophthalmology, University Hospital Basel, 4031, Basel, Switzerland.
Sci Rep. 2022 Mar 7;12(1):3695. doi: 10.1038/s41598-022-07439-2.
Optical coherence tomography angiography (OCTA) enables three-dimensional, high-resolution, depth-resolved flow to be distinguished from non-vessel tissue signals in the retina. Thus, it enables the quantification of the 3D surface area of the retinal vessel signal. Despite the widespread use of OCTA, no representative spatially rendered reference vessel surface area data are published. In this study, the OCTA vessel surface areas in 203 eyes of 107 healthy participants were measured in the 3D domain. A Generalized Linear Model (GLM) model analysis was performed to investigate the effects of sex, age, spherical equivalent, axial length, and visual acuity on the OCTA vessel surface area. The mean overall vessel surface area was 54.53 mm (range from 27.03 to 88.7 mm). OCTA vessel surface area was slightly negatively correlated with age. However, the GLM model analysis identified axial length as having the strongest effect on OCTA vessel surface area. No significant correlations were found for sex or between left and right eyes. This is the first study to characterize three-dimensional vascular parameters in a population based on OCTA with respect to the vessel surface area.
光学相干断层扫描血管造影（OCTA）能够区分视网膜中三维、高分辨率、深度分辨的血流信号与非血管组织信号。因此，它能够对视网膜血管信号的三维表面积进行量化。尽管OCTA已被广泛应用，但尚未有代表性的空间呈现的参考血管表面积数据发表。在本研究中，对107名健康参与者的203只眼睛进行了OCTA血管表面积的三维测量。进行了广义线性模型（GLM）分析，以研究性别、年龄、等效球镜度、眼轴长度和视力对OCTA血管表面积的影响。总体血管表面积的平均值为54.53平方毫米（范围为27.03至88.7平方毫米）。OCTA血管表面积与年龄呈轻度负相关。然而，GLM模型分析确定眼轴长度对OCTA血管表面积的影响最大。未发现性别或左右眼之间存在显著相关性。这是第一项基于OCTA对人群血管表面积的三维血管参数进行表征的研究。
