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Drugging SUMOylation for neuroprotection and oncotherapy.

作者信息

Bernstock Joshua D, Ye Daniel G, Lee Yang-Ja, Gessler Florian, Friedman Gregory K, Zheng Wei, Hallenbeck John M

机构信息

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA; Department of Clinical Neurosciences - Division of Stem Cell Neurobiology, Wellcome Trust-Medical Research Council Stem Cell Institute and NIHR Biomedical Research Centre, University of Cambridge, UK.

Stroke Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health (NINDS/NIH), Bethesda, MD, USA.

出版信息

Neural Regen Res. 2018 Mar;13(3):415-416. doi: 10.4103/1673-5374.228718.

DOI:10.4103/1673-5374.228718
PMID:29623920
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5900498/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/5900498/695e980c301a/NRR-13-415-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/5900498/695e980c301a/NRR-13-415-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/32e6/5900498/695e980c301a/NRR-13-415-g001.jpg

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本文引用的文献

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SUMOylation in brain ischemia: Patterns, targets, and translational implications.脑缺血中的 SUMOylation：模式、靶标和转化意义。
J Cereb Blood Flow Metab. 2018 Jan;38(1):5-16. doi: 10.1177/0271678X17742260. Epub 2017 Nov 17.
2
Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2.高通量定量筛选鉴定出通过抑制 SUMO 特异性蛋白酶 (SENP)2 增强 SUMO 缀合的细胞保护分子。
FASEB J. 2018 Mar;32(3):1677-1691. doi: 10.1096/fj.201700711R. Epub 2018 Jan 3.
3
Drug discovery: Controlling protein SUMOylation.
Pharmaceuticals (Basel). 2023 Apr 29;16(5):673. doi: 10.3390/ph16050673.
4
Toll-like receptors in sepsis-associated cytokine storm and their endogenous negative regulators as future immunomodulatory targets.脓毒症相关细胞因子风暴中的 Toll 样受体及其内源性负性调节因子作为未来的免疫调节靶点。
Int Immunopharmacol. 2020 Dec;89(Pt B):107087. doi: 10.1016/j.intimp.2020.107087. Epub 2020 Oct 12.
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Ubiquitin and Ubiquitin-Like Proteins in the Critical Equilibrium between Synapse Physiology and Intellectual Disability.泛素及类泛素蛋白在突触生理学与智力残疾之间的关键平衡中所起的作用
eNeuro. 2020 Aug 26;7(4). doi: 10.1523/ENEURO.0137-20.2020. Print 2020 Jul/Aug.
6
Post-translational modifications of the Fragile X Mental Retardation Protein in neuronal function and dysfunction.脆性 X 智力低下蛋白的翻译后修饰在神经元功能和功能障碍中的作用。
Mol Psychiatry. 2020 Aug;25(8):1688-1703. doi: 10.1038/s41380-019-0629-4. Epub 2019 Dec 10.
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SAE1 promotes human glioma progression through activating AKT SUMOylation-mediated signaling pathways.SAE1 通过激活 AKT SUMOylation 介导的信号通路促进人胶质瘤的进展。
Cell Commun Signal. 2019 Jul 25;17(1):82. doi: 10.1186/s12964-019-0392-9.
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SUMOylation in Glioblastoma: A Novel Therapeutic Target.脑胶质瘤中的 SUMOylation：一种新的治疗靶点。
Int J Mol Sci. 2019 Apr 15;20(8):1853. doi: 10.3390/ijms20081853.
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EBioMedicine. 2019 Apr;42:214-224. doi: 10.1016/j.ebiom.2019.03.035. Epub 2019 Mar 21.
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Drug Discov Today. 2016 Jul;21(7):1189-95. doi: 10.1016/j.drudis.2016.05.015. Epub 2016 May 27.
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J Neurochem. 2016 Jul;138(1):101-16. doi: 10.1111/jnc.13643. Epub 2016 Jun 6.
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A novel quantitative high-throughput screen identifies drugs that both activate SUMO conjugation via the inhibition of microRNAs 182 and 183 and facilitate neuroprotection in a model of oxygen and glucose deprivation.一种新型定量高通量筛选方法鉴定出了两类药物，一类通过抑制微小RNA 182和183来激活SUMO缀合，另一类在氧糖剥夺模型中具有神经保护作用。
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