Department of Neurosurgery, University of Alabama at Birmingham, 1060 Faculty Office Tower, 510 20th Street South, Birmingham, AL 35223, USA.
Medical Scientist Training Program, University of Alabama at Birmingham, 1825 University Boulevard, SHEL 121, Birmingham, AL 35294, USA.
Int J Mol Sci. 2019 Apr 15;20(8):1853. doi: 10.3390/ijms20081853.
Protein SUMOylation is a dynamic post-translational modification which is involved in a diverse set of physiologic processes throughout the cell. Of note, SUMOylation also plays a role in the pathobiology of a myriad of cancers, one of which is glioblastoma (GBM). Accordingly, herein, we review core aspects of SUMOylation as it relates to GBM and in so doing highlight putative methods/modalities capable of therapeutically engaging the pathway for treatment of this deadly neoplasm.
蛋白质 SUMOylation 是一种动态的翻译后修饰，它参与了细胞内各种生理过程。值得注意的是，SUMOylation 也在多种癌症的病理生物学中发挥作用，其中一种是神经胶质瘤（GBM）。因此，本文综述了 SUMOylation 与 GBM 相关的核心方面，并在此过程中强调了可能有能力通过治疗性地参与该途径来治疗这种致命肿瘤的方法/模式。
