Applied Organic Chemistry, Chemical Sciences & Technology Division , CSIR-North East Institute of Science and Technology, AcSIR , Jorhat 785006 , India.
Org Lett. 2018 Apr 20;20(8):2297-2300. doi: 10.1021/acs.orglett.8b00643. Epub 2018 Apr 6.
An unprecedented Ru(II)-catalyzed C-H activation and annulation reaction, which proceeds via C-C triple bond cleavage, is reported. This reaction of 2-phenyldihydrophthalazinediones with alkynes, which works most efficiently in the presence of bidented ligand 1,3-bis(diphenylphosphino)propane, affords good yields of substituted quinazolines.
报道了首例 Ru(II)-催化的 C-H 活化和环化反应，该反应通过 C-C 三键断裂进行。该反应中，2-苯并二氢邻苯二甲酰亚胺与炔烃反应，在双齿配体 1,3-双(二苯基膦)丙烷的存在下反应效率最高，可得到取代的喹唑啉。
