Applied Organic Chemistry, Chemical Sciences & Technology Division , CSIR-North East Institute of Science and Technology , Jorhat 785006 , AcSIR, India.
Org Lett. 2018 Jul 6;20(13):3753-3757. doi: 10.1021/acs.orglett.8b01330. Epub 2018 Jun 13.
A novel Ru(II)-catalyzed C-H activation and annulation reaction of N-arylpyrazol-5-ones and diaryl/arylalkyl-substituted alkynes is developed. Unlike the reported metal-catalyzed C-H activation and annulation reactions, in the present bidentate amine-ligand controlled C-H activation and annulation reaction, the annulation occurs via a 1,2-aryl shift to afford quaternary carbon-centered pyrimidoindolones.
开发了一种新型 Ru(II)催化的 N-芳基吡唑-5-酮和二芳基/芳基烷基取代炔烃的 C-H 活化和环化反应。与报道的金属催化的 C-H 活化和环化反应不同，在本研究的双齿胺配体控制的 C-H 活化和环化反应中，环化反应通过 1,2-芳基迁移进行，得到季碳中心嘧啶并吲哚酮。
