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会阴创伤与HIV垂直传播的审计

An Audit of Perineal Trauma and Vertical Transmisson Of HIV.

作者信息

Ocheke Amaka N, Samuels Ephraim, Ocheke Isaac E, Agaba Patricia A, Ekere Clement, Bitrus James, Agaba Emmanuel I, Sagay Atiene S

机构信息

Department of Obstetrics and Gynaecology.

Department of Paediatrics.

出版信息

Afr J Reprod Health. 2017 Dec;21(4):67-72. doi: 10.29063/ajrh2017/v21i4.7.

Abstract

Restrictive episiotomy is recommended for the prevention of vertical transmission of HIV. The study compared the frequency of episiotomy use and the occurrence of perineal tears; and related factors in HIV positive and HIV negative women and to assess their effect on Mother-to-child transmission (MTCT) of HIV. A total of 110 HIV positive and 134 HIV negative parturients were enrolled in the study. The incidence of episiotomy was more in the HIV negative group (p=0.0000) while that of perineal tear was not affected by HIV status (p=0.17). The rate of episiotomy was significantly affected by primigravidity in HIV negative subjects (OR= 0.032, 95% CI 0.0072-0.13). The rate of perineal tear was significantly affected by primigravidity in HIV positive subjects (OR=8.55, 95% CI 1.91-38.7) and multigravidity in HIV negative subjects (OR= 0.030, 95% CI 0.133-0.71). Gestational age and mean birth weight had no effect on the rate of episiotomy (p value =0.57 and 0.30) and perineal tear (p value= 0.79 and 0.061). There was no mother-to-child HIV transmission. Episiotomies should be given when needed irrespective of HIV status because of the risk of consequent perineal tear and with HAART the risk of MTCT from perineal trauma is minimal.

摘要

建议采用限制性会阴切开术以预防艾滋病毒的垂直传播。该研究比较了会阴切开术的使用频率和会阴撕裂的发生率;以及艾滋病毒阳性和阴性女性的相关因素,并评估它们对艾滋病毒母婴传播(MTCT)的影响。共有110名艾滋病毒阳性产妇和134名艾滋病毒阴性产妇纳入该研究。艾滋病毒阴性组的会阴切开术发生率更高(p = 0.0000),而会阴撕裂的发生率不受艾滋病毒感染状况的影响(p = 0.17)。艾滋病毒阴性受试者的初孕情况对会阴切开术发生率有显著影响(OR = 0.032,95%可信区间0.0072 - 0.13)。艾滋病毒阳性受试者的初孕情况(OR = 8.55,95%可信区间1.91 - 38.7)和艾滋病毒阴性受试者的经孕情况(OR = 0.030,95%可信区间0.133 - 0.71)对会阴撕裂发生率有显著影响。孕周和平均出生体重对会阴切开术发生率(p值 = 0.57和0.30)以及会阴撕裂发生率(p值 = 0.79和0.061)均无影响。未发生艾滋病毒母婴传播。由于存在会阴撕裂的风险,无论艾滋病毒感染状况如何,应在需要时进行会阴切开术,并且在高效抗逆转录病毒治疗(HAART)的情况下,因会阴创伤导致的母婴传播风险极小。

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