Van Steenberge A, Debroux H C, Noorduin H
Department of Anaesthesiology, Hospital St Anne, Brussels, Belgium.
Br J Anaesth. 1987 Dec;59(12):1518-22. doi: 10.1093/bja/59.12.1518.
The combination of sufentanil with bupivacaine plus adrenaline given extradurally for pain relief during labour was studied in a double-blind trial. One hundred and twenty patients were randomly divided into three groups and received a 10-ml extradural injection of sufentanil 15 micrograms + bupivacaine 12.5 mg + adrenaline 12.5 micrograms, sufentanil 7.5 micrograms + bupivacaine 12.5 mg + adrenaline 12.5 micrograms, or bupivacaine 12.5 mg + adrenaline 12.5 micrograms (control group). A second injection, which was given upon request, was identical to the first. Subsequently, patients received a further 10 ml of bupivacaine + adrenaline, if required. The addition of sufentanil significantly decreased the latency, and increased the duration, of the analgesia. Moreover, the quality of analgesia was better and less bupivacaine was required, resulting in less motor blockade at delivery. There were no differences between the three groups in regard to Apgar scores. The only side effect of sufentanil was pruritus.
在一项双盲试验中，研究了舒芬太尼与布比卡因加肾上腺素联合硬膜外给药用于分娩镇痛的效果。120例患者被随机分为三组，分别接受10毫升硬膜外注射舒芬太尼15微克+布比卡因12.5毫克+肾上腺素12.5微克、舒芬太尼7.5微克+布比卡因12.5毫克+肾上腺素12.5微克或布比卡因12.5毫克+肾上腺素12.5微克（对照组）。应要求给予的第二次注射与第一次相同。随后，如有需要，患者再接受10毫升布比卡因+肾上腺素。添加舒芬太尼显著缩短了镇痛潜伏期，并延长了镇痛持续时间。此外，镇痛质量更好，所需布比卡因更少，导致分娩时运动阻滞减轻。三组之间的阿氏评分没有差异。舒芬太尼的唯一副作用是瘙痒。
