Vertommen J D, Lemmens E, Van Aken H
Department of Anaesthesiology, University Hospital, Katholieke Universiteit Leuven, Belgium.
Anaesthesia. 1994 Aug;49(8):678-81. doi: 10.1111/j.1365-2044.1994.tb04396.x.
In a double-blind, randomised, prospective study 150 women in labour received intermittent epidural injections of 10 ml 0.125% bupivacaine with adrenaline (1:800,000) with 5, 7.5 or 10 micrograms of sufentanil added. The onset, duration, and quality of analgesia were compared. Motor block, type of delivery and neonatal Apgar scores were noted. The onset, duration, and quality of analgesia were generally similar in the three groups, except following the second injection when the quality of analgesia was significantly superior in the sufentanil 7.5 and 10 micrograms groups. Motor blockade and type of delivery did not differ between the groups and there were no differences in neonatal Apgar scores. No patient required more than three injections. We conclude that 7.5 micrograms sufentanil is the optimal dose to add to intermittent epidural injections of 10 ml 0.125% bupivacaine with adrenaline (1:800,000) for pain relief in labour.
在一项双盲、随机、前瞻性研究中，150名分娩中的女性接受了间歇性硬膜外注射10毫升含肾上腺素（1:800,000）的0.125%布比卡因，并分别添加了5、7.5或10微克的舒芬太尼。比较了镇痛的起效时间、持续时间和质量。记录了运动阻滞、分娩方式和新生儿阿普加评分。三组的镇痛起效时间、持续时间和质量总体相似，但在第二次注射后，7.5微克和10微克舒芬太尼组的镇痛质量明显更优。各组之间的运动阻滞和分娩方式没有差异，新生儿阿普加评分也没有差异。没有患者需要超过三次注射。我们得出结论，对于分娩时缓解疼痛，7.5微克舒芬太尼是添加到10毫升含肾上腺素（1:800,000）的0.125%布比卡因间歇性硬膜外注射中的最佳剂量。
