Csernansky J G, Mellentin J, Beauclair L, Lombrozo L
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, CA.
Biol Psychiatry. 1988 Feb 1;23(3):285-94. doi: 10.1016/0006-3223(88)90039-x.
Limbic seizures developed in rats following daily electrical stimulation of the basolateral nucleus of the amygdala. Animals were designated as "kindled" after five complete (stage 5) behavioral seizures were observed. A subgroup, designated as "superkindled," received three additional weeks of electrical stimulations. Kindled rats were significantly subsensitive to the stereotypy-inducing effects of apomorphine, a direct dopamine agonist, compared to controls. Superkindled rats were supersensitive to the effects of apomorphine. However, both kindled and superkindled rats demonstrated an increase in 3H-spiperone Bmax values, reflecting dopamine D2-receptor densities, in the nucleus accumbens ipsilateral to the stimulating electrode. The number of interictal spikes recorded from the stimulating amygdaloid electrode during the last week of kindling was correlated with changes in apomorphine sensitivity in individual animals.
在大鼠中，每日对杏仁核基底外侧核进行电刺激后会引发边缘系统癫痫发作。在观察到五次完整的（第5阶段）行为性癫痫发作后，动物被认定为“点燃”。一个被指定为“超点燃”的亚组接受了额外三周的电刺激。与对照组相比，点燃的大鼠对直接多巴胺激动剂阿扑吗啡的刻板诱导作用明显不敏感。超点燃的大鼠对阿扑吗啡的作用超敏感。然而，点燃和超点燃的大鼠在与刺激电极同侧的伏隔核中，反映多巴胺D2受体密度的3H-螺哌隆Bmax值均有所增加。在点燃的最后一周，从刺激杏仁核电极记录到的发作间期棘波数量与个体动物中阿扑吗啡敏感性的变化相关。
