Ehlers C L, Koob G F
Brain Res. 1985 Feb 4;326(1):71-9. doi: 10.1016/0006-8993(85)91385-x.
Spontaneous and drug-induced interictal and post-ictal locomotor behavior of rats was investigated following electrical 'kindling' of different limbic structures at 3 brain sites which differ in the relative amount of innervation from dopamine cells of the ventral tegmentum: nucleus accumbens (N.Acc.), amygdala (AMYG), and dorsal hippocampus (DHPC). Kindling produced decreases in spontaneous post-ictal locomotion that did not appear to depend on the site of stimulation, but produced region specific attenuations in spontaneous interictal behavior as well as amphetamine-induced interictal and post-ictal responses. The most dramatic decreases were seen in N.Acc. kindled animals and the least dramatic were seen in rats kindled via DHPC. These data suggest that the mesolimbic dopamine system may participate in the changes in locomotion seen following kindled seizures, and may also provide a model for the study of human post-ictal and interictal behavior.
在三个脑区对不同边缘结构进行电“点燃”后，研究了大鼠的自发及药物诱导的发作间期和发作后期运动行为。这三个脑区腹侧被盖区多巴胺能细胞的神经支配相对量不同，分别为伏隔核（N.Acc.）、杏仁核（AMYG）和背侧海马（DHPC）。点燃导致发作后期自发运动减少，这似乎不依赖于刺激部位，但在发作间期自发行为以及苯丙胺诱导的发作间期和发作后期反应中产生了区域特异性减弱。在伏隔核点燃的动物中观察到最显著的减少，而通过背侧海马点燃的大鼠中减少最不明显。这些数据表明，中脑边缘多巴胺系统可能参与了点燃性癫痫发作后出现的运动变化，也可能为研究人类发作后期和发作间期行为提供一个模型。
