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使用THP-1巨噬细胞模型评估药物对脓肿分枝杆菌的细胞内活性。

Evaluation of the intracellular activity of drugs against Mycobacterium abscessus using a THP-1 macrophage model.

作者信息

Molina-Torres Carmen Amelia, Tamez-Peña Lorena, Castro-Garza Jorge, Ocampo-Candiani Jorge, Vera-Cabrera Lucio

机构信息

Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico.

Servicio de Dermatología, Hospital Universitario, Universidad Autónoma de Nuevo León, Monterrey, N.L., Mexico.

出版信息

J Microbiol Methods. 2018 May;148:29-32. doi: 10.1016/j.mimet.2018.03.020. Epub 2018 Apr 4.

DOI:10.1016/j.mimet.2018.03.020
PMID:29626567
Abstract

We evaluated the antimicrobial effectiveness against M. abscessus in a THP-1 cell line model. No intracellular activity was observed when using amikacin or imipenem. A bacteriostatic effect was observed for cefoxitin, clarithromycin and azithromycin. Tigecycline showed the best antibacterial effect by decreasing the intracellular growth up to bactericidal level.

摘要

我们在THP-1细胞系模型中评估了对脓肿分枝杆菌的抗菌效果。使用阿米卡星或亚胺培南时未观察到细胞内活性。观察到头孢西丁、克拉霉素和阿奇霉素有抑菌作用。替加环素通过将细胞内生长降低至杀菌水平显示出最佳抗菌效果。

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