Department of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza, Campus Río Ebro - Edificio I+D, C/ Poeta Mariano Esquillor S/N, 50018 Zaragoza, Spain; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
Department of Chemical Engineering, Aragon Institute of Nanoscience (INA), University of Zaragoza, Campus Río Ebro - Edificio I+D, C/ Poeta Mariano Esquillor S/N, 50018 Zaragoza, Spain; Aragon Health Research Institute (IIS Aragón), 50009 Zaragoza, Spain.
J Colloid Interface Sci. 2018 Aug 1;523:234-244. doi: 10.1016/j.jcis.2018.03.107. Epub 2018 Mar 30.
Near-infrared (NIR) responsive nanoparticles are of great interest in the biomedical field as antennas for photothermal therapy and also as triggers for on-demand drug delivery. The present work reports the preparation of hollow gold nanoparticles (HGNPs) with plasmonic absorption in the NIR region covalently bound to a thermoresponsive polymeric shell that can be used as an on-demand drug delivery system for the release of analgesic drugs. The photothermal heating induced by the nanoparticles is able to produce the collapse of the polymeric shell thus generating the release of the local anesthetic bupivacaine in a spatiotemporally controlled way. Those HGNPs contain a 10 wt.% of polymer and present excellent reversible heating under NIR light excitation. Bupivacaine released at physiological temperature (37 °C) showed a pseudo-zero order release that could be spatiotemporally modified on-demand after applying several pulses of light/temperature above and below the lower critical solution temperature (LCST) of the polymeric shell. Furthermore, the nanomaterials obtained did not displayed detrimental effects on four mammalian cell lines at doses up to 0.2 mg/mL. From the results obtained it can be concluded than this type of hybrid thermoresponsive nanoparticle can be used as an externally activated on-demand drug delivery system.
近红外（NIR）响应纳米粒子作为光热治疗的天线，以及作为按需药物输送的触发物，在生物医学领域引起了极大的兴趣。本工作报道了通过共价键合到具有光热响应聚合物壳的中空金纳米粒子（HGNPs）的制备，该壳可作为用于释放镇痛药的按需药物输送系统。纳米粒子的光热加热能够产生聚合物壳的塌陷，从而以时空控制的方式释放局部麻醉剂布比卡因。那些 HGNPs 含有 10wt%的聚合物，在近红外光激发下表现出优异的可逆加热性能。在生理温度（37°C）下释放的布比卡因呈现出伪零级释放，在施加几次高于和低于聚合物壳的低临界溶液温度（LCST）的光/温度脉冲后，可以按需进行时空修饰。此外，在高达 0.2mg/mL 的剂量下，所获得的纳米材料在四种哺乳动物细胞系中没有显示出有害影响。从获得的结果可以得出结论，这种混合热响应纳米粒子可以用作外部激活的按需药物输送系统。
