Molecular Imaging and Therapy Service, Memorial Sloan Kettering Cancer Center, New York, NY.; Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY.; Department of Diagnostic Radiology, Keio University School of Medicine, Tokyo, Japan.
Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY.
Semin Nucl Med. 2018 May;48(3):291-298. doi: 10.1053/j.semnuclmed.2018.02.004. Epub 2018 Mar 9.
Molecular imaging provides multiple imaging techniques to identify characteristics of vulnerable plaque including I) Inflammatory cells (the presence and metabolic activity of macrophages), II) synthesis of lipid and fatty acid in the plaque, III) the presence of hypoxia in severely inflamed lesions, IV) expression of factors stimulating angiogenesis, V) expression of protease enzymes in the lesion, VI) development of microthrombi in late-phase lesions, VII) apoptosis, and VIII) microcalcification.
分子成像是一种多模态的影像学方法，用于识别易损斑块的特征，包括：I）炎症细胞（巨噬细胞的存在和代谢活性）；II）斑块内脂质和脂肪酸的合成；III）严重炎症病变中的缺氧；IV）刺激血管生成的因子表达；V）病变中蛋白酶的表达；VI）晚期病变中微血栓的形成；VII）细胞凋亡；VIII）微钙化。
