Department of Pediatrics, Division of Neonatology, Wake Forest School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157.
Department of Pediatrics, Divisions of Neonatology and Pediatric Infectious Diseases, Center for Perinatal Research, Nationwide Children's Hospital, The Ohio State University College of Medicine, 700 Children's Drive, RB3, WB5245, Columbus, OH 43205-2664.
Semin Perinatol. 2018 Apr;42(3):176-184. doi: 10.1053/j.semperi.2018.02.005. Epub 2018 Apr 5.
Congenital syphilis remains a major public health problem worldwide, and its incidence is increasing in the United States. This review highlights the ongoing problem of this preventable infection, and discusses vertical transmission and clinical manifestations while providing a practical algorithm for the evaluation and management of infants born to mothers with reactive serologic tests for syphilis. Every case of congenital syphilis must be seen as a failure of our public health system to provide optimal prenatal care to pregnant women, as congenital syphilis can be prevented by early and repeated prenatal serologic screening of mothers and penicillin treatment of infected women, their sexual partners, and their newborn infants.
先天性梅毒仍然是全球一个主要的公共卫生问题，其发病率在美国呈上升趋势。本综述强调了这种可预防感染的持续存在问题，并讨论了垂直传播和临床表现，同时为母亲血清学检测反应性梅毒的婴儿的评估和管理提供了实用的算法。每一例先天性梅毒都应被视为我们公共卫生系统未能为孕妇提供最佳产前护理的失败，因为通过对母亲进行早期和重复的产前血清学筛查，以及对感染的妇女、其性伴侣和新生儿进行青霉素治疗，可以预防先天性梅毒。
