Department of Pediatrics, Division of Neonatology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, RB3, WB5245, Columbus, OH 43205-2664, USA; Department of Pediatrics, Division of Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University College of Medicine, Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, RB3, WB5245, Columbus, OH 43205-2664, USA.
Department of Pediatrics, Division of Neonatology, Nationwide Children's Hospital, The Ohio State University College of Medicine, Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, RB3, WB5245, Columbus, OH 43205-2664, USA; Department of Pediatrics, Division of Pediatric Infectious Diseases, Nationwide Children's Hospital, The Ohio State University College of Medicine, Center for Perinatal Research, Abigail Wexner Research Institute at Nationwide Children's Hospital, 700 Children's Drive, RB3, WB5245, Columbus, OH 43205-2664, USA.
Clin Perinatol. 2021 Jun;48(2):293-309. doi: 10.1016/j.clp.2021.03.005.
Syphilis in neonates and infants remains a significant public health problem because it is a major cause of fetal and neonatal morbidity and mortality globally. Despite decades of experience with syphilis in adults and infants, maternal and congenital syphilis are increasing substantially in the United States. The vertical transmission, clinical manifestations, diagnosis, evaluation, treatment, and follow-up are reviewed to guide the health care professional in understanding the optimal management of this preventable disease.
先天性梅毒仍然是一个重大的公共卫生问题，因为它是导致胎儿和新生儿发病和死亡的一个主要原因，这在全球范围内都是如此。尽管几十年来人们对成人和婴儿的梅毒都有了一定的经验，但在美国，梅毒的母婴传播和先天梅毒仍在大幅增加。本文回顾了梅毒的垂直传播、临床表现、诊断、评估、治疗和随访，以指导医疗保健专业人员了解这种可预防疾病的最佳管理方法。
