Trauma Research Dept, Swedish Medical Center, Englewood, CO 80113, United States.
Trauma Research Dept, Swedish Medical Center, Englewood, CO 80113, United States; St. Anthony Hospital, Lakewood, CO 80228, United States; Medical City Plano, Plano, TX 75075, United States; Penrose Hospital, Colorado Springs, CO 80907, United States; Research Medical Center, Kansas City, MO 64132, United States; Wesley Medical Center, Wichita, KS 67214, United States.
Clin Chim Acta. 2018 Jul;482:149-154. doi: 10.1016/j.cca.2018.04.008. Epub 2018 Apr 6.
Within the first few hours of a traumatic brain injury, the activity of extracellular matrix degradative enzymes increases. As a result, the blood brain barrier becomes disrupted as secondary white matter injury increases. Anoikis, a form of apoptosis, results from cells detaching from the extracellular matrix leading to cell death. This "homelessness" (anoikis) of cells hinders recovery progression, exacerbating brain injury while disrupting synaptic plasticity and other central nervous system functions. Here, we discuss the current knowledge of molecular pathways and proteins involved in both the activation and inhibition of anoikis.
在创伤性脑损伤发生后的最初几个小时内，细胞外基质降解酶的活性增加。结果，血脑屏障被破坏，继发性白质损伤增加。细胞凋亡是一种细胞死亡形式，是由于细胞从细胞外基质上脱离而导致的。这种细胞的“无家可归”（细胞凋亡）会阻碍恢复进程，加重脑损伤，同时破坏突触可塑性和中枢神经系统的其他功能。在这里，我们讨论了参与细胞凋亡激活和抑制的分子途径和蛋白质的现有知识。
