Jeremy J Y, Mikhailidis D P, Thompson C S, Dandona P
Department of Chemical Pathology and Human Metabolism, Royal Free Hospital and School of Medicine, London, UK.
Diabetes Res. 1987 Oct;6(2):95-8.
The effect of streptozotocin-induced diabetes mellitus (DM) on rat brain prostanoid synthesis was assessed. Prostacyclin (PGI2) synthesis was significantly reduced in the DM animals in all 3 brain regions studied (cerebrum; cerebellum; brain stem). In contrast, the synthesis of the other 3 prostanoids assessed (PGF2 alpha; PGE2; TXA2) was not significantly altered in the DM animals. Insulin treatment reverted PGI2 synthesis towards the normal pattern. Since PGI2 is a vasodilator and the other 3 prostanoids (PGF2 alpha; PGE2; TXA2) are cerebral vasoconstrictors, these changes may be relevant to the pathogenesis of the previously reported abnormalities of cerebral blood flow and the increased incidence of cerebrovascular disease in DM.
评估了链脲佐菌素诱导的糖尿病（DM）对大鼠脑前列腺素合成的影响。在所研究的所有3个脑区（大脑、小脑、脑干）中，糖尿病动物的前列环素（PGI2）合成显著降低。相比之下，所评估的其他3种前列腺素（PGF2α、PGE2、TXA2）的合成在糖尿病动物中未发生显著改变。胰岛素治疗使PGI2合成恢复到正常模式。由于PGI2是一种血管舒张剂，而其他3种前列腺素（PGF2α、PGE2、TXA2）是脑血管收缩剂，这些变化可能与先前报道的糖尿病患者脑血流异常及脑血管疾病发病率增加的发病机制有关。
