Kim Bong Kyun, Oh Se Jeong, Song Jeong-Yoon, Lee Han-Byoel, Park Min Ho, Jung Yongsik, Park Woo-Chan, Lee Jina, Sun Woo Young
Department of Surgery, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
Department of Surgery, Incheon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Incheon, Korea.
J Breast Cancer. 2018 Mar;21(1):62-69. doi: 10.4048/jbc.2018.21.1.62. Epub 2018 Mar 23.
Breast cancer is one of the most common malignancies worldwide and the second most common cancer among Korean women. The prognosis of breast cancer is poor in patients with other primary cancers. However, there have been few clinical studies regarding this issue. Therefore, we analyzed the characteristics and prognosis of patients with breast cancer with multiple primary cancers (MPCs).
Data from the Korean Breast Cancer Society Registry were analyzed. Data from enrolled patients who underwent surgery for breast cancer were analyzed for differences in prognosis dependent on the presence of MPCs, and which MPC characteristics affected their prognosis.
Among the 41,841 patients analyzed, 913 patients were found to have MPCs, accounting for 950 total MPCs. There was a significant difference in survival rates between the breast cancer only group and the MPC group. The 5-year survival rates were 93.6% and 86.7% and the 10-year survival rates were 87.5% and 70.4%, respectively. Among the 913 patients with MPCs, patients with two or more MPCs had significantly worse prognoses than patients with a single MPC. With respect to the time interval between breast cancer and MPC occurrence, patients with a 5-year or greater interval had significantly better prognoses than patients with less than 1 year between occurrences. Among MPCs, thyroid cancer was the most common primary cancer. However, this type was not related to the prognosis of breast cancer. Gynecologic cancer, colorectal cancer, upper gastrointestinal cancer, and lung cancer were related to breast cancer prognosis.
MPCs were a poor prognostic factor for patients with breast cancer. Two or more MPCs and a shorter time interval between occurrences were worse prognostic factors. Although MPCs were a poor prognostic factor, thyroid cancer did not affect the prognosis of patients with breast cancer.
乳腺癌是全球最常见的恶性肿瘤之一，在韩国女性中是第二常见的癌症。患有其他原发性癌症的乳腺癌患者预后较差。然而，关于这个问题的临床研究很少。因此，我们分析了患有多种原发性癌症（MPC）的乳腺癌患者的特征和预后。
分析了韩国乳腺癌协会登记处的数据。对接受乳腺癌手术的登记患者的数据进行分析，以探讨MPC的存在对预后的影响，以及哪些MPC特征会影响其预后。
在分析的41,841例患者中，发现913例患者患有MPC，共950个MPC。仅患乳腺癌组和MPC组的生存率存在显著差异。5年生存率分别为93.6%和86.7%，10年生存率分别为87.5%和70.4%。在913例患有MPC的患者中，患有两种或更多MPC的患者预后明显比仅患有单个MPC的患者差。关于乳腺癌和MPC发生之间的时间间隔，间隔5年或更长时间的患者预后明显好于发生间隔少于1年的患者。在MPC中，甲状腺癌是最常见的原发性癌症。然而，这种类型与乳腺癌的预后无关。妇科癌症、结直肠癌、上消化道癌症和肺癌与乳腺癌预后相关。
MPC是乳腺癌患者预后不良的因素。两种或更多MPC以及发生间隔较短是预后较差的因素。虽然MPC是预后不良的因素，但甲状腺癌不影响乳腺癌患者的预后。
