Kwon Jin-Hee, Kim Heyjin, Lee Jin Kyung, Hong Young Jun, Kang Hye Jin, Jang Yoon Jung
Medical Science Demonstration Center, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea.
Department of Laboratory Medicine, Korea Cancer Center Hospital, Korea Institute of Radiological and Medical Sciences, Seoul 01812, Republic of Korea.
Cancers (Basel). 2024 Jun 26;16(13):2346. doi: 10.3390/cancers16132346.
Rising cancer survival rates have led to an increased risk of multiple primary cancers (MPCs). Data on MPCs in South Korea are limited. This study aimed to address incidence and clinical characteristics of MPCs in a single cancer center in Korea during a 20-year period. We retrospectively analyzed 96,174 cancer patients at the Korea Cancer Center Hospital between 2003 and 2022, identifying 2167 patients with metachronous MPCs based on Surveillance, Epidemiology, and End Results SEER criteria. We categorized patients by cancer type (15 major solid cancer groups and 3 major hematologic cancer groups), including pathological diagnosis, assessed latency periods, and relative risks (RRs) for developing MPCs. The overall MPC incidence was 2.3%. Breast cancer (15.7%) was the most common primary cancer, and lung cancer (15.2%) was the most frequent second primary cancer. The median latency period for second primary cancers was 4.1 years. Decreasing latency periods for third and fourth primary cancers were observed (2.1 years and 1.6 years, respectively). Most cancers maintained their dominant pathological type despite notable changes in the prevalence of specific pathologies for certain types of second primaries. Lymphoma showed the highest RR (2.1) for developing MPCs. Significant associations were found between specific primary and subsequent cancers, including breast-ovary, thyroid-breast, stomach-pancreas, colorectal-head and neck, lung-prostate, and lymphoma-myeloid neoplasms. These findings contribute to a better understanding of MPC occurrence. They can inform future research on their etiology and development of improved management strategies.
癌症生存率的提高导致了多原发性癌症（MPCs）风险的增加。韩国关于MPCs的数据有限。本研究旨在探讨韩国某单一癌症中心20年间MPCs的发病率及临床特征。我们回顾性分析了2003年至2022年间韩国癌症中心医院的96174例癌症患者，根据监测、流行病学和最终结果（SEER）标准确定了2167例异时性MPCs患者。我们按癌症类型（15个主要实体癌组和3个主要血液癌组）对患者进行分类，包括病理诊断、评估潜伏期以及发生MPCs的相对风险（RRs）。MPCs的总体发病率为2.3%。乳腺癌（15.7%）是最常见的原发性癌症，肺癌（15.2%）是最常见的第二原发性癌症。第二原发性癌症的中位潜伏期为4.1年。观察到第三和第四原发性癌症的潜伏期缩短（分别为2.1年和1.6年）。尽管某些类型的第二原发性癌症的特定病理患病率有显著变化，但大多数癌症仍保持其主要病理类型。淋巴瘤发生MPCs的RR最高（2.1）。在特定的原发性癌症与后续癌症之间发现了显著关联，包括乳腺-卵巢、甲状腺-乳腺、胃-胰腺、结直肠-头颈部、肺-前列腺以及淋巴瘤-髓系肿瘤。这些发现有助于更好地理解MPCs的发生情况。它们可为未来关于其病因学的研究以及改进管理策略的制定提供参考。
