Small M, Simpson I, McGhie I, Douglas J T, Lowe G D, Forbes C D
University Department of Medicine, Royal Infirmary, Glasgow, UK.
Haemostasis. 1987;17(6):371-6. doi: 10.1159/000215772.
Plasma levels of B beta 15-42 peptide and fibrinopeptide A (FPA) were measured as indicators of plasmin-mediated fibrin(ogen)olysis and thrombin activity of fibrinogen in 34 middle-aged men, at rest and following a standard exercise test. In the group as a whole no significant changes in B beta 15-42 or FPA were noted after exercise. When the group was subdivided into men with (n = 20) and without (controls n = 14) coronary heart disease, exercise-stimulated thrombin and plasmin generation was found only in the control group who exercised for a significantly longer duration. The rise in B beta 15-42 was related to both the intensity and duration of exercise. Similar increases in plasma fibrinolytic activity (fibrin plate) occurred in both groups and no other differences in the components of the fibrinolytic system (plasminogen, alpha 2-antiplasmin, fibrin degradation product) were noted either after exercise or between the groups. Exercise in normal middle-aged men is associated with modest thrombin and plasmin activation.
在34名中年男性休息时及进行标准运动试验后，检测血浆Bβ15 - 42肽和纤维蛋白肽A（FPA）水平，作为纤溶酶介导的纤维蛋白（原）溶解和纤维蛋白原凝血酶活性的指标。在整个组中，运动后未观察到Bβ15 - 42或FPA有显著变化。当该组被分为患有冠心病的男性（n = 20）和未患冠心病的男性（对照组n = 14）时，仅在运动持续时间明显更长的对照组中发现运动刺激的凝血酶和纤溶酶生成。Bβ15 - 42的升高与运动强度和持续时间均有关。两组血浆纤溶活性（纤维蛋白平板法）均有类似升高，且运动后或两组之间在纤溶系统成分（纤溶酶原、α2 - 抗纤溶酶、纤维蛋白降解产物）方面未发现其他差异。正常中年男性运动与适度的凝血酶和纤溶酶激活有关。
