Hyers T M, Martin B J, Pratt D S, Dreisin R B, Franks J J
J Appl Physiol Respir Environ Exerc Physiol. 1980 May;48(5):821-5. doi: 10.1152/jappl.1980.48.5.821.
We measured products of thrombin and plasmin action and of the platelet release reaction during exercise to determine if the well-known effect of exercise on in vitro coagulation and fibrinolytic tests reflects activity of these systems in vivo. Plasma fibrinopeptide A, produced by thrombin-mediated proteolysis of fibrinogen, increased with graded treadmill and cycle exercise to postexercise levels of 20--30 times resting values. Fibrin/fibrinogen-related D antigen increased in a similar fashion with peak levels at maximal O2 uptake. Plasma-activated partial thromboplastin times fell as fibrinopeptide A levels increased. Unheated fibrin plate lysis areas increased as D antigen concentrations rose, indicating increased release of plasminogen activator. In contrast to activation of the soluble coagulation and fibrinolytic systems, platelet counts and plasma levels of beta-thromboglobulin, a platelet release protein, did not change significantly with exercise. The effect of exercise on thrombin and plasmin was not influenced by prior physical training, but appeared to be less with cycle exercise than with treadmill exercise.
我们测量了运动过程中凝血酶和纤溶酶作用产物以及血小板释放反应，以确定运动对体外凝血和纤溶试验的众所周知的影响是否反映了这些系统在体内的活性。凝血酶介导纤维蛋白原蛋白水解产生的血浆纤维蛋白肽A，随着分级跑步机运动和骑自行车运动而增加，运动后水平达到静息值的20 - 30倍。纤维蛋白/纤维蛋白原相关D抗原以类似方式增加，在最大摄氧量时达到峰值水平。随着纤维蛋白肽A水平升高，血浆活化部分凝血活酶时间缩短。未加热的纤维蛋白平板溶解面积随着D抗原浓度升高而增加，表明纤溶酶原激活物释放增加。与可溶性凝血和纤溶系统的激活相反，血小板计数以及血小板释放蛋白β-血小板球蛋白的血浆水平在运动时没有显著变化。运动对凝血酶和纤溶酶的影响不受先前体育训练的影响，但骑自行车运动的影响似乎小于跑步机运动。
