冠状动脉疾病中的凝血酶和纤溶酶活性
Thrombin and plasmin activity in coronary artery disease.
作者信息
Small M, Lowe G D, Douglas J T, Hutton I, Lorimer A R, Forbes C D
机构信息
University Department of Medicine, Royal Infirmary, Glasgow.
出版信息
Br Heart J. 1988 Sep;60(3):201-3. doi: 10.1136/hrt.60.3.201.
Basal plasmin and thrombin activity in plasma were assessed by radioimmunoassay of the fibrinogen derivatives containing the sequence B beta 15-42 and of fibrinopeptide A respectively in a cross sectional controlled study of men with coronary artery disease. Compared with healthy controls (n = 33) men with angiographically defined coronary artery disease (n = 98) had a modest but significant increase in concentrations of fibrinopeptide A, indicating an activated coagulation system. Concentrations of B beta 15-42 were similar in those with coronary artery disease and in the controls. The enhanced thrombin activity in coronary artery disease is in keeping with current evidence suggesting an association between coronary artery disease and a hypercoagulable state.
在一项针对冠心病男性患者的横断面对照研究中，分别通过对含有Bβ15 - 42序列的纤维蛋白原衍生物和纤维蛋白肽A进行放射免疫测定，来评估血浆中的基础纤溶酶和凝血酶活性。与健康对照组（n = 33）相比，经血管造影确诊为冠心病的男性患者（n = 98）的纤维蛋白肽A浓度有适度但显著的升高，这表明凝血系统被激活。冠心病患者和对照组中Bβ15 - 42的浓度相似。冠心病中凝血酶活性增强与目前表明冠心病和高凝状态之间存在关联的证据相符。
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