De Paoli P, Carbone A, Battistin S, Crovatto M, Arreghini N, Santini G
Servizio di Microbiologia-Immunologia, Ospedale Civile, Pordenone, Italy.
Immunol Lett. 1987 Oct;16(1):71-3. doi: 10.1016/0165-2478(87)90064-2.
We have used 4B4 and 2H4 monoclonal antibodies in conjunction with OKT 4 to quantify T cell subsets in lymph node suspensions from human immunodeficiency virus (HIV) positive subjects with lymphadenopathy syndrome. The data indicate that the reduced OKT 4:OKT 8 ratio was due to a depletion of the OKT 4+ 4B4+ subset. In contrast, there were no differences compared to reactive controls, considering the OKT8+ subpopulation. These alterations may be related to the immunological deficiency associated with HIV infection.
我们使用4B4和2H4单克隆抗体联合OKT 4来定量检测患有淋巴结病综合征的人类免疫缺陷病毒（HIV）阳性受试者淋巴结悬液中的T细胞亚群。数据表明，OKT 4:OKT 8比值降低是由于OKT 4+ 4B4+亚群的耗竭。相比之下，就OKT8+亚群而言，与反应性对照组相比没有差异。这些改变可能与HIV感染相关的免疫缺陷有关。
