Cohen Rony, Halevy Ayelet, Aharon Sharon, Shuper Avinoam
Neurofibromatosis Clinic, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
Department of Pediatric Neurology and Epilepsy Center, Schneider Children's Medical Center of Israel, Petach Tikva, Israel.
J Clin Neurol. 2018 Apr;14(2):153-157. doi: 10.3988/jcn.2018.14.2.153.
The objective of this study was to determine if the MOXO visual- and vocal-distractors-based continuous performance test distinguishes patients with attention deficit hyperactivity disorder (ADHD) and neurofibromatosis type 1 (NF1) from those without NF1.
Thirty-five patients (16 males; mean age 9.91 years) attending a multidisciplinary NF1 clinic completed the MOXO test. The findings were compared to 532 healthy age-matched standardized control subjects (285 males) without ADHD.
The overall performance in the MOXO text was significantly worse in the NF1 group than in controls (p<0.01), but no group-specific pattern was identified. Impulsivity and hyperactivity were significantly more prominent in males than females (p<0.01). Compared to controls, the NF1 group exhibited significantly more failures to respond to target stimuli in the presence of visual distractors.
MOXO scores are abnormal in patients with NF1, but the test cannot differentiate between NF1 with ADHD characteristics and ADHD. The test highlights sex differences in ADHD characteristics in NF1. Overreactivity to visual distractors may form part of the attention deficit in NF1.
本研究的目的是确定基于MOXO视觉和语音干扰物的持续性操作测试能否区分患有注意力缺陷多动障碍（ADHD）的1型神经纤维瘤病（NF1）患者与无NF1的患者。
35名在多学科NF1诊所就诊的患者（16名男性；平均年龄9.91岁）完成了MOXO测试。将结果与532名年龄匹配、无ADHD的健康标准化对照受试者（285名男性）进行比较。
NF1组在MOXO测试中的总体表现显著差于对照组（p<0.01），但未发现特定组别的模式。冲动和多动在男性中比女性更显著（p<0.01）。与对照组相比，NF1组在存在视觉干扰物时对目标刺激的反应失败明显更多。
NF1患者的MOXO分数异常，但该测试无法区分具有ADHD特征的NF1患者和ADHD患者。该测试突出了NF1中ADHD特征的性别差异。对视觉干扰物的过度反应可能是NF1注意力缺陷的一部分。
