Mu Wei-Qiang, Huang Xia-Yu, Zhang Jiang, Liu Xiao-Cong, Huang Mao-Mao
Jingdezhen City Hospital of Traditional Chinese Medicine, Jingdezhen, China.
BMJ Open. 2018 Apr 9;8(4):e020123. doi: 10.1136/bmjopen-2017-020123.
Osteoporosis (OP) has been defined as a degenerative bone disease characterised by low bone mass and microstructural deterioration of bone tissue, leading to fragility and an increased risk of fractures, especially of the hip, spine and wrist. Exercise has been shown to benefit the maintenance of bone health and improvement of muscle strength, balance and coordination, thereby reducing the risk of falls and fractures. However, prior findings regarding the optimal types and regimens of exercise for treating low bone mineral density (BMD) in elderly people are not consistent. As an important component of traditional Chinese Qigong exercises, Tai Chi (TC) is an ancient art and science of healthcare derived from the martial arts. The objective of this study is to attempt to conduct a systematic review and meta-analysis of the existing studies on TC exercise as an intervention for the prevention or treatment of OP in elderly adults and to draw more useful conclusions regarding the safety and the effectiveness of TC in preventing or treating OP.
Eight electronic databases (Science Citation Index, PubMed Database, Embase (Ovid) Database, the Cochrane Central Register of Controlled Trials, and Chinese databases, including Chinese BioMedical Database, China National Knowledge Infrastructure, Wanfang database and the Chongqing VIP Chinese Science and Technology Periodical Database) will be searched from the beginning of each database to 1 April 2018. Potential outcomes of interest will include rates of fractures or falls, BMD at the total hip and the total spine, bone formation biomarkers, bone resorption biomarkers, bone biomarkers, health-related quality of life and adverse events. Only randomised controlled trials comparing TC exercise against each other or non-intervention will be included. The Cochrane risk of bias assessment tool will be used for quality assessment.
Ethical approval is not required as the study will be a review of existing studies. This review may help to elucidate whether TC exercise is effective for the prevention or treatment of OP in elderly adults. The findings of the study will be published in a peer-reviewed publication and will be disseminated electronically or in print. We will share the findings in the fourth quarter of 2018.
CRD42018084950.
骨质疏松症（OP）被定义为一种退行性骨病，其特征为骨量低和骨组织微结构退化，导致骨骼脆弱以及骨折风险增加，尤其是髋部、脊柱和腕部骨折。运动已被证明有益于维持骨骼健康，并改善肌肉力量、平衡和协调性，从而降低跌倒和骨折的风险。然而，先前关于治疗老年人低骨矿物质密度（BMD）的最佳运动类型和方案的研究结果并不一致。太极拳（TC）作为中国传统气功练习的一个重要组成部分，是一种源自武术的古老保健艺术与科学。本研究的目的是尝试对现有的关于TC运动作为预防或治疗老年人OP的干预措施的研究进行系统评价和荟萃分析，并就TC在预防或治疗OP方面的安全性和有效性得出更有用的结论。
将检索八个电子数据库（科学引文索引、PubMed数据库、Embase（Ovid）数据库、Cochrane对照试验中心注册库以及中文数据库，包括中国生物医学数据库、中国知网、万方数据库和重庆维普中文科技期刊数据库），检索时间从每个数据库建库起始至2018年4月1日。感兴趣的潜在结果将包括骨折或跌倒发生率、全髋和全脊柱的骨密度、骨形成生物标志物、骨吸收生物标志物、骨生物标志物、健康相关生活质量和不良事件。仅纳入比较TC运动与其他运动或非干预措施的随机对照试验。将使用Cochrane偏倚风险评估工具进行质量评估。
由于本研究将对现有研究进行综述，因此无需伦理批准。本综述可能有助于阐明TC运动对预防或治疗老年人OP是否有效。研究结果将发表在同行评审的出版物上，并将以电子或印刷形式传播。我们将在2018年第四季度分享研究结果。
CRD42018084950。
