Manzillo G, Maio G, Izzo C M, Fiorentino F, De Sena R, Simioli F, Cozzolino C, Pignalosa G, Sbreglia C, Manzillo E
Centri Provinciali di Riferimento per la Vaccinazione anti-epatite B, Napoli, Ospedale Cotugno.
Minerva Med. 1988 Jan;79(1):15-28.
The results obtained at the end of the first three years of a hepatitis B vaccination campaign in Campania, are reported. HEVAC-B and H-B-VAX proved innocuous and efficacious in producing anti-HBs. Newborn babies and children produced anti-HBs more often and with higher titres than adults. Titre 10 mUI/ml of anti-HBs persisted, in the responders for at least 36 months on average. AVH by HBV was observed in two adult non responders. Transplacental or delivery infection was observed in 9.3% of the babies born of HBsAg positive mothers and more often among babies born of HBeAg positive mothers. Infection by HBV was observed in 6.0% of the babies, in 4.0% of the children and in 12.0% of the adults, in spite of the production of anti-HBs. HB-antigenemia, was as a rule transitory, but sometimes fluctuating or persistent. Careful observation during a prolonged follow up is necessary for these subjects.
报告了坎帕尼亚地区乙肝疫苗接种运动头三年结束时获得的结果。HEVAC - B和H - B - VAX在产生抗 - HBs方面被证明是无害且有效的。新生儿和儿童产生抗 - HBs的频率比成年人更高，且滴度更高。在应答者中，抗 - HBs滴度为10 mUI/ml平均至少持续36个月。在两名成年无应答者中观察到了乙肝病毒引起的急性病毒性肝炎。在HBsAg阳性母亲所生的婴儿中，9.3%观察到经胎盘或分娩时感染，在HBeAg阳性母亲所生的婴儿中更常见。尽管产生了抗 - HBs，但在6.0%的婴儿、4.0%的儿童和12.0%的成年人中观察到了乙肝病毒感染。乙肝抗原血症通常是短暂的，但有时会波动或持续。对这些受试者进行长期随访期间的仔细观察是必要的。
