两款市售胰岛素泵贴片的脉搏准确性比较研究。

A Comparative Pulse Accuracy Study of Two Commercially Available Patch Insulin Infusion Pumps.

作者信息

Bowen Jenna L, Allender Chris J

机构信息

School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff, UK.

出版信息

Eur Endocrinol. 2016 Aug;12(2):79-84. doi: 10.17925/EE.2016.12.02.79. Epub 2016 Aug 28.

Patch pumps are a relatively new method of Insulin delivery. This study explores the accuracy of patch-pumps by reporting on comparative pulse-accuracy study of two patch pumps. The accuracy of two patch pumps (Cellnovo, [Cellnovo Ltd., Swansea, UK] and OmniPod [Ypsomed Ltd, Escrick, UK]) was evaluated micro-gravimetrically. Pulse accuracy was analysed by comparing single and time-averaged pulses for each device. Single-pulses outside accuracy thresholds ±5%, ±10%, ±15%, ±20%, ±25% and ±30% were: Cellnovo; 79.6%, 55.6%, 35.0%, 19.9%, 9.7% and 4.3%; OmniPod; 86.2%, 71.6%, 57.4%, 45.5%, 35.2% and 25.4%. For 10, 20 and 40 pulse-windows mean values outside ±15% accuracy level were: Cellnovo; 7.3%, 1.5% and 0.4%, OmniPod; 37.6%, 31.8% and 25.9. This study showed that not all patch pumps are the same. The pumping mechanisms employed in these pumps play a significant role in the accuracy and precision of such devices.

贴片式胰岛素泵是一种相对较新的胰岛素给药方式。本研究通过报告两种贴片式胰岛素泵的脉冲准确性对比研究，来探究贴片式胰岛素泵的准确性。采用微量重力分析法评估了两种贴片式胰岛素泵（Cellnovo，[英国斯旺西的Cellnovo有限公司]和OmniPod[英国埃斯克里克的Ypsomed有限公司]）的准确性。通过比较每个设备的单次脉冲和时间平均脉冲来分析脉冲准确性。超出±5%、±10%、±15%、±20%、±25%和±30%准确性阈值的单次脉冲比例分别为：Cellnovo胰岛素泵，79.6%、55.6%、35.0%、19.9%、9.7%和4.3%；OmniPod胰岛素泵，86.2%、71.6%、57.4%、45.5%、35.2%和25.4%。在10次、20次和40次脉冲窗口中，超出±15%准确性水平的平均值分别为：Cellnovo胰岛素泵，7.3%、1.5%和0.4%；OmniPod胰岛素泵，37.6%、31.8%和25.9%。本研究表明，并非所有贴片式胰岛素泵都是一样的。这些胰岛素泵所采用的泵送机制在这类设备的准确性和精度方面起着重要作用。