1 Institut für Diabetes-Technologie, Forschungs- und Entwicklungsgesellschaft mbH an der Universität Ulm, Ulm, Germany.
2 Diabetes Clinic for Children and Adolescents, Muenster, Germany.
Diabetes Technol Ther. 2019 Apr;21(4):201-208. doi: 10.1089/dia.2018.0376. Epub 2019 Mar 22.
Insulin pumps are used for basal rate and bolus insulin delivery in patients with diabetes. In this in vitro study, accuracy of delivery of different commercial insulin pumps was evaluated.
Accuracy of 10 different insulin pump systems (5 durable pumps with different insulin infusion sets and 1 patch pump) was tested with a microgravimetric method. Mean bolus accuracy of 25 successive 1 U boluses and of 12 successive 10 U boluses was assessed, and delivery time for 10 U boluses was measured. Basal rate accuracy at 1.0 U/h was evaluated for 72 h and for individual 1-h windows.
Mean bolus delivery was within ±5% of target for both tested bolus sizes, but precision of individual boluses was higher with the larger boluses. Delivery times varied between the different pump models but agreed with the specifications of the respective manufacturers. Regarding basal rate accuracy, the total deviation for 72 h was very small in all pumps; however, larger deviations were observed during the first 12 h. For the patch pump, large variations between individual 1-h windows were observed.
In general, all compared insulin pump systems showed a similar level of accuracy. Differences, especially between durable pumps and the patch pump, were observed when considering each hour of basal rate delivery separately.
胰岛素泵用于糖尿病患者的基础率和推注胰岛素输送。在这项体外研究中，评估了不同商业胰岛素泵的输送准确性。
使用微量重量法测试了 10 种不同胰岛素泵系统（5 种带有不同胰岛素输注套件的耐用泵和 1 种贴片泵）的准确性。评估了 25 次连续 1U 推注和 12 次连续 10U 推注的平均推注准确性，并测量了 10U 推注的输送时间。在 72 小时和单独的 1 小时窗口评估了 1.0U/h 的基础率准确性。
两种测试剂量的平均推注输送均在目标值的±5%范围内，但较大剂量的单个推注精度更高。输送时间在不同的泵模型之间有所不同，但与各自制造商的规格相符。关于基础率准确性，所有泵在 72 小时内的总偏差都很小；然而，在前 12 小时内观察到较大的偏差。对于贴片泵，单独的 1 小时窗口之间观察到较大的变化。
一般来说，所有比较的胰岛素泵系统都表现出相似的准确性水平。当分别考虑每个小时的基础率输送时，耐用泵和贴片泵之间观察到了差异。
