癌症患者的缺血性脑卒中：一种被低估的病理学综述。
Ischemic stroke in cancer patients: A review of an underappreciated pathology.
机构信息
Department of Neurology.
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine.
出版信息
Ann Neurol. 2018 May;83(5):873-883. doi: 10.1002/ana.25227. Epub 2018 Apr 30.
Abstract
Currently 1 in 10 patients with ischemic stroke have comorbid cancer, and this frequency is expected to increase with continued advances in cancer therapeutics prolonging median survival. Well known for its association with venous thrombosis, cancer has recently emerged as a significant risk factor for arterial thromboembolism, including stroke; however, the underlying mechanisms are uncertain. In addition, the optimal strategies to prevent and acutely treat stroke in cancer patients are yet to be established. This review summarizes the current evidence on ischemic stroke risk, biomarkers, pathophysiology, treatments, and prognosis in cancer patients, emphasizing knowledge gaps and the potential strategies to address them. Ann Neurol 2018;83:873-883.
摘要
目前，缺血性脑卒中患者中有 10%合并癌症，且随着癌症治疗方法的不断进步，中位生存期延长，这一比例预计将会增加。癌症以其与静脉血栓形成的相关性而广为人知，最近已成为包括脑卒中在内的动脉血栓栓塞事件的重要危险因素；然而，其潜在机制尚不确定。此外，预防和急性治疗癌症患者脑卒中的最佳策略尚未建立。本综述总结了目前关于癌症患者缺血性脑卒中风险、生物标志物、病理生理学、治疗和预后的证据，强调了知识空白和潜在的解决策略。《神经病学年鉴》2018 年；83：873-883.
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