Strain W D, Hope S V, Green A, Kar P, Valabhji J, Sinclair A J
Diabetes and Vascular Research Centre, University of Exeter Medical School, Medical Academic Staff Committee, Lead Physician, Academic Department of Healthcare for the Older Person, Royal Devon and Exeter Hospital Trust, and British Medical Association Medical Academic Staff Committee.
Secretary, British Geriatrics Society Special Interest Group in Diabetes, and University of Exeter Medical School.
Diabet Med. 2018 Jul;35(7):838-845. doi: 10.1111/dme.13644. Epub 2018 May 6.
Rates of population ageing are unprecedented and this, combined with the progressive urbanization of lifestyles, has led to a dramatic shift in the epidemiology of diabetes towards old age, particularly to those aged 60-79 years. Both ageing and diabetes are recognized as important risk factors for the development of functional decline and disability. In addition, diabetes is associated with a high economic, social and health burden. Traditional macrovascular and microvascular complications of diabetes appear to account for less than half of the diabetes-related disability observed in older people. Despite this, older adults are under-represented in clinical trials. Guidelines from organizations such as the National Institute for Health and Care Excellence (NICE), the European Association for the Study of Diabetes, and the American Diabetes Association acknowledge the need for individualized care, but the glycaemic targets that are suggested to constitute good control [HbA 53-59 mmol/mol (7-7.5%)] are too tight for frail older individuals. We present a framework for the assessment of older adults and guidelines for the management of this population according to their frailty status, with the intention of reducing complications and improving quality of life for these people.
人口老龄化速度空前,再加上生活方式的逐步城市化,导致糖尿病流行病学发生了巨大转变,发病年龄趋于老年化,尤其是60 - 79岁人群。老龄化和糖尿病都被认为是功能衰退和残疾发展的重要风险因素。此外,糖尿病还伴随着高昂的经济、社会和健康负担。糖尿病传统的大血管和微血管并发症似乎只占老年人中观察到的与糖尿病相关残疾的不到一半。尽管如此,老年人在临床试验中的代表性不足。英国国家卫生与临床优化研究所(NICE)、欧洲糖尿病研究协会和美国糖尿病协会等组织的指南都承认需要个性化护理,但建议的构成良好控制的血糖目标[糖化血红蛋白53 - 59 mmol/mol(7 - 7.5%)]对体弱的老年人来说过于严格。我们提出了一个评估老年人的框架以及根据其虚弱状况管理这一人群的指南,旨在减少这些人的并发症并提高其生活质量。