Pascarella A, Fiorenza S, Masotta O, Tibollo V, Vella D, Nardone Anna Maria, Rossi Marta, Volanti P, Madonia F, Cstronovo Gaetano, De Cicco D, Guarnaschelli Caterina, Achilli M P, Chiapparino C, Angelillo M T, Tommasi M A, Pisano F, Grioni G, Vezzadini G, Ferriero G, Salvaderi S, Bellazzi R, Estraneo Anna
Funct Neurol. 2018 Jan/Mar;33(1):19-30. doi: 10.11138/fneur/2018.33.1.019.
Diagnostic accuracy and reliable estimation of clinical evolution are challenging issues in the management of patients with disorders of consciousness (DoC). Longitudinal systematic investigations conducted in large cohorts of patients with DoC could make it possible to identify reliable diagnostic and prognostic markers. On the basis of this consideration, we devised a multicentre prospective registry for patients with DoC admitted to ten intensive rehabilitation units. The registry collects homogeneous and detailed data on patients' demographic and clinical features, neurophysiological and neuroimaging findings, and medical and surgical complications. Here we present the rationale and the design of the registry and the preliminary results obtained in 53 patients with DoC (vegetative state or minimally conscious state) enrolled during the first seven months of the study. Data at 6-month post-injury follow-up were available for 46 of them. This registry could be an important tool for collecting high-quality data through the application of rigorous methods, and it could be used in the routine management of patients with DoC admitted to rehabilitation settings.
在意识障碍（DoC）患者的管理中，诊断准确性和对临床进展的可靠评估是具有挑战性的问题。在大量意识障碍患者队列中进行纵向系统研究，有可能识别出可靠的诊断和预后标志物。基于这一考虑，我们为入住十个强化康复单元的意识障碍患者设计了一个多中心前瞻性登记系统。该登记系统收集有关患者人口统计学和临床特征、神经生理学和神经影像学检查结果以及医疗和手术并发症的统一且详细的数据。在此，我们介绍该登记系统的基本原理、设计以及在研究的前七个月纳入的53例意识障碍（植物状态或微意识状态）患者所获得的初步结果。其中46例患者有受伤后6个月的随访数据。这个登记系统可能是通过应用严格方法收集高质量数据的重要工具，可用于入住康复机构的意识障碍患者的常规管理。
