Khater Dooa
.
Acta Biomed. 2018 Mar 27;89(1):117-121. doi: 10.23750/abm.v89i1.7119.
Celiac disease (CD) is a systemic, immune mediated and genetically determined small intestinal disorder characterized by intolerance to dietary gluten that generally presents with gastrointestinal symptoms in young children and extra-intestinal manifestations. Furthermore, there is close association between CD and endocrine diseases, including diabetes, autoimmune thyroid diseases, growth and pubertal disorders, etc. probably due to the presence of a common genetic predisposition. The present review aims to highlight and give more insight to the endocrine changes in CD, especially when there are few or no gastrointestinal symptoms and to emphasize on screening opportunities in some endocrine diseases.
乳糜泻(CD)是一种全身性、免疫介导且由基因决定的小肠疾病,其特征为对膳食麸质不耐受,通常在幼儿期出现胃肠道症状及肠外表现。此外,CD与内分泌疾病密切相关,包括糖尿病、自身免疫性甲状腺疾病、生长及青春期障碍等,这可能是由于存在共同的遗传易感性。本综述旨在突出并更深入了解CD中的内分泌变化,尤其是在胃肠道症状很少或没有的情况下,并强调某些内分泌疾病的筛查机会。