College of Chemistry and Chemical Engineering , Northwest Normal University , Lanzhou , Gansu 730070 , P. R. China.
Org Lett. 2018 Apr 20;20(8):2342-2345. doi: 10.1021/acs.orglett.8b00676. Epub 2018 Apr 10.
A new methodology for the construction of methyl-substituted benzofuran rings from the reactions of calcium carbide with salicylaldehyde p-tosylhydrazones/2-hydroxyacetophenone p-tosylhydrazones is described. Various 2-methylbenzofurans and 2,3-dimethylbenzofurans could be obtained in satisfactory yield by using a cuprous chloride catalyst. The advantages of this protocol include the use of a readily available and easy-to-handle acetylene source and simple workup procedure.
本文描述了一种从碳化钙与水杨醛对甲苯腙/2-羟基苯乙酮对甲苯腙的反应出发构建甲基取代苯并呋喃环的新方法。使用氯化亚铜催化剂，可以以满意的产率得到各种 2-甲基苯并呋喃和 2,3-二甲基苯并呋喃。该方法的优点包括使用易得且易于处理的乙炔源和简单的后处理步骤。
