Hefei National Laboratory for Physical Sciences at the Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, Anhui, China.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, Gansu, China.
Molecules. 2020 Aug 14;25(16):3719. doi: 10.3390/molecules25163719.
The solvent-free mechanochemical reaction has aroused increasing interest among scientists. Mechanical ball-milling can implement reactions under mild conditions, shorten the reaction time, and improve the reaction efficiency. Particularly, the most attractive characteristic of mechanochemistry is that it can alter the reaction pathway. However, few such examples have been reported so far. In this paper, we report the reaction of aldoximes with NaCl and Oxone under ball-milling conditions to afford -acyloxyimidoyl chlorides, which are different from those of the liquid-phase counterpart.
无溶剂的机械化学反应用引起了科学家们越来越多的兴趣。机械球磨可以在温和的条件下实施反应，缩短反应时间，提高反应效率。特别地，机械化学最吸引人的特点是它可以改变反应途径。然而，到目前为止，这样的例子还很少。在本文中，我们报告了在球磨条件下醛肟与 NaCl 和 Oxone 的反应，生成了不同于液相对应物的 -acyloxyimidoyl 氯化物。
