Division of Imaging, Diagnostics, and Software Reliability, Office of Science and Engineering Laboratories, Center for Devices and Radiological Health, Food and Drug Administration, Silver Spring, MD 20993, United States of America. Fischell Department of Bioengineering, University of Maryland, College Park, MD 20742, United States of America.
Phys Med Biol. 2018 May 4;63(9):09NT01. doi: 10.1088/1361-6560/aabd1f.
We report a novel method for developing gelatin-based phantom materials for transmission x-ray imaging with high stability at room temperature and tunable x-ray attenuation properties. This is achieved by efficiently cross-linking gelatin in a glycerin solution with only 10% water by volume and systematically decreasing their x-ray attenuation coefficients by doping with microbubbles that are originally designed to be used as lightweight additives for paints and crack fillers. For demonstration, we mimic breast glandular and adipose tissues by using such gelatin materials and also study the feasibility of 3D printing them based on the extrusion-based technique. Results from x-ray spectroscopy (15-45 keV) show the materials to have stable x-ray attenuation properties of glandular and adipose tissues over a period of two months. Micro-CT analysis of independently prepared samples shows the materials to be uniform and easy to reproduce with minimum variability in attenuation values. These materials can be used to 3D print realistic phantoms that mimic x-ray properties of various biological tissues.
我们报告了一种新的方法，用于开发基于明胶的体模材料，用于室温下的传输 X 射线成像，具有高稳定性和可调谐的 X 射线衰减特性。这是通过在甘油溶液中有效地交联明胶来实现的，其中水的体积含量仅为 10%，并通过掺杂微泡来系统地降低其 X 射线衰减系数，这些微泡最初被设计用作油漆和裂缝填充剂的轻质添加剂。为了进行演示，我们使用这种明胶材料模拟乳腺腺组织和脂肪组织，并研究基于挤出技术的 3D 打印它们的可行性。X 射线光谱（15-45keV）的结果表明，这些材料在两个月的时间内具有稳定的腺组织和脂肪组织的 X 射线衰减特性。对独立制备的样品进行的微 CT 分析表明，这些材料均匀且易于复制，衰减值的变化最小。这些材料可用于 3D 打印逼真的体模，模拟各种生物组织的 X 射线特性。
