Mehmood Amir, Hamid Irfan, Sharif Ali, Akhtar Muhammad Furqan, Aljtar Bushra, Saleem Ammara, Iqbal Javed, Shabbir Maryam, Ali Sajid
Acta Pol Pharm. 2016 Nov;73(6):1601-1608.
The present study was designed to evaluate the anti-inflammatory, analgesic and antipyretic activities of the aqueous and ethanolic extracts of seeds of Buchanania lanzan Spreng. Albino mice were used as experimental animals to evaluate these activities. The study was performed in three phases; Phase-I for evaluation of anti-inflammatory activity, Phase-II for antipyretic and Phase-HI for analgesic activities were evaluated. Carrageenan induced paw edema, brewer yeast induced pyrexia and acetic acid induced writhing methods were used to evaluate anti-inflammatory, antipyretic and analgesic activities, respectively. Tests were performed by dividing the animals in five groups. First group was negative control, second group was positive control, third, fourth and fifth groups were treated with 125, 250 and 500 mg/kg of extracts. respectively. The data were statistically analyzed using ANOVA where p < 0.05 were considered significant. The results suggested that seeds of Buchanania lanzan Spreng. possess anti-inflammatory, analgesic and antipyretic activity.
本研究旨在评估兰撒罗望子种子水提取物和乙醇提取物的抗炎、镇痛和解热活性。以白化小鼠作为实验动物来评估这些活性。该研究分三个阶段进行；第一阶段评估抗炎活性，第二阶段评估解热活性，第三阶段评估镇痛活性。分别采用角叉菜胶诱导的爪肿胀、啤酒酵母诱导的发热以及醋酸诱导的扭体方法来评估抗炎、解热和镇痛活性。通过将动物分为五组来进行实验。第一组为阴性对照，第二组为阳性对照，第三、第四和第五组分别用125、250和500 mg/kg的提取物进行处理。使用方差分析对数据进行统计学分析，其中p < 0.05被认为具有显著性。结果表明，兰撒罗望子种子具有抗炎、镇痛和解热活性。
