Ivanova N A, Taros L Iu, Nevedomskaia G N, Kudriavtseva V K, Medvedeva T E
Vopr Virusol. 1987 Sep-Oct;32(5):528-33.
Comparative studies of biological properties of influenza A (H3N2) viruses isolated in the epidemics of 1980 and 1983 and in the interepidemic period of 1982 showed a sharp reduction of the biological activity of the interepidemic viruses as compared with that of the epidemic ones. This was manifested by low isolation rate of virus in the interepidemic period, reduced hemagglutinating, interfering, and immunogenic activity of these viruses, poor reproduction in the lung tissue of white mice and the lack of virus-specific syntheses in splenocytes of infected Syrian hamsters. Unlike epidemic strains, the interepidemic strains had ts mutation in gene 6 coding for neuraminidase. There are reasons to associate the observed defect in gene 6 with frequent development of asymptomatic forms of influenza infection in the interepidemic period.
对1980年和1983年流感流行期间以及1982年流行间期分离出的甲型（H3N2）流感病毒生物学特性的比较研究表明，与流行期病毒相比，流行间期病毒的生物学活性急剧降低。这表现为流行间期病毒的分离率低、血凝、干扰和免疫原活性降低、在小白鼠肺组织中的繁殖能力差以及感染的叙利亚仓鼠脾细胞中缺乏病毒特异性合成。与流行株不同，流行间期毒株在编码神经氨酸酶的基因6中存在温度敏感（ts）突变。有理由将观察到的基因6缺陷与流行间期流感感染无症状形式的频繁发生联系起来。
