Isaeva E I, Ivanova V T, Rovnova Z I, Oskerko T A, Alipova T A
Vopr Virusol. 1994 Mar-Apr;39(2):62-5.
The antigenic structure of hemagglutinin (HA) of influenza A (H3N2) viruses was found to have undergone significant changes which markedly distinguished the new isolates of previously occurring strains. Investigations of the epidemic variants using monospecific and monoclonal antibodies revealed strains with original HA sites previously unfound in H3N2 viruses. The emergence of the sites with the new properties determined the epidemic activity of the viruses isolated in this period.
甲型流感（H3N2）病毒血凝素（HA）的抗原结构发生了显著变化，这使得新分离出的病毒与之前出现的毒株明显不同。使用单特异性抗体和单克隆抗体对流行变异株进行研究发现，这些毒株具有先前在H3N2病毒中未发现的原始HA位点。具有新特性的位点的出现决定了这一时期分离出的病毒的流行活性。
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