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酷似眼眶蜂窝织炎的上颌淋巴瘤;病例报告及文献复习

Lymphoma Maxilla mimicking orbital cellulitis; case report and review of Literature.

作者信息

Shah Shankar P, Chetri S T, Paudyal Poonam, Lavaju P, Shah B P, Misra S

出版信息

Nepal J Ophthalmol. 2017 Jul;9(18):180-186. doi: 10.3126/nepjoph.v9i2.19266.

Abstract

BACKGROUND

Sinonasal lymphomas are the commonest nonepithelial malignancies of the nasal cavity and paranasal sinuses. They may spread from their site of origin in nasal cavity and invade adjacent structures including orbits leading to varying presentation and a diagnostic dilemma.

CASE

A-77- year old Nepalese male presented with swelling of left eye since 1 month and pain in the same eye since 2 days.

OBSERVATION

Examination revealed axial proptosis, swelling of lids, restricted extraocular movement, diffuse conjunctival and ciliary congestion with chemosis. Visual acuity was grossly decreased. The case was diagnosed as left orbital cellulitis and treated with broad spectrum intravenous antibiotics and oral steriods. There was no response despite 3 days of antibiotics and steroids therefore a computed tomography was planned which showed features of Sinonasal malignancy invading the orbit. Repeated biopsy was suggestive of malignant small round cell tumour. In the view of unclear preoperative biopsy indicating further details on the histologic type of tumor and extensive erosion of maxilla with complete loss of vision in the eye the patient was planned for Total Maxillectomy with Orbital extenteration of the left orbit. Post-operative histopathological and Immunohistochemical report were suggestive of High grade Lymphoma. The patient was advised for Adjuvant Chemotherapy and Radiotherapy, which the patient refused due to financial constraints. He is on occasional follow up since the last 6 months.

CONCLUSIONS

The diagnosis of maxillary sinus lymphoma needs to be borne in mind when a clinician encounters a case of Orbital Cellulitis. It may be difficult to diagnose clinically and require radio-pathological correlation.

摘要

背景

鼻窦淋巴瘤是鼻腔和鼻窦最常见的非上皮性恶性肿瘤。它们可能从鼻腔的起源部位扩散,侵犯包括眼眶在内的邻近结构,导致不同的表现和诊断困境。

病例

一名77岁的尼泊尔男性,1个月来左眼肿胀,2天来同一眼疼痛。

观察

检查发现眼球轴向突出、眼睑肿胀、眼球运动受限、结膜和睫状肌弥漫性充血伴水肿。视力严重下降。该病例被诊断为左眼眶蜂窝织炎,接受了广谱静脉抗生素和口服类固醇治疗。尽管使用了3天抗生素和类固醇,但仍无反应,因此计划进行计算机断层扫描,结果显示鼻窦恶性肿瘤侵犯眼眶的特征。反复活检提示为恶性小圆形细胞瘤。鉴于术前活检结果不明确,无法进一步明确肿瘤的组织学类型,且上颌骨广泛侵蚀,患眼完全失明,计划对该患者进行全上颌骨切除并左眼眶内容剜除术。术后组织病理学和免疫组织化学报告提示为高级别淋巴瘤。建议患者进行辅助化疗和放疗,但患者因经济原因拒绝。自最近6个月以来,他偶尔接受随访。

结论

当临床医生遇到眼眶蜂窝织炎病例时,需要考虑上颌窦淋巴瘤的诊断。临床上可能难以诊断,需要影像学与病理学相结合。

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