Ubrs GmbH, Postfach, Basel, 4058, Switzerland.
BASF SE, Ludwigshafen, Germany.
Reprod Toxicol. 2018 Jun;78:102-110. doi: 10.1016/j.reprotox.2018.04.005. Epub 2018 Apr 7.
Ethanolamine (EA) reduced implantation success in a two-generation reproduction toxicity study; the aim of this work was to explore the underlying basis for this response. When administered to pregnant rats during gestation days (GD) 1-3, 4-5, or 6-7, EA had no effect upon implantation success. In a second experiment, EA was administered either in the diet or by oral gavage from two weeks prior to mating through to GD 8. Parallel groups also received a diet supplemented with choline. In the absence of supplementary choline, EA induced early resorptions, statistically significant only when administered in the diet. A slight reduction in implantation success was ameliorated by supplementary choline. We conclude that implantation is affected by EA only when exposure starts before mating; that dietary administration is more effective than gavage dosing; and that interference with choline homeostasis may play a role in the aetiology of this lesion.
乙醇胺 (EA) 降低了两代生殖毒性研究中的着床成功率；本工作旨在探讨这种反应的潜在基础。当在妊娠第 1-3、4-5 或 6-7 天给予怀孕大鼠时，EA 对着床成功率没有影响。在第二个实验中，EA 通过饮食或口服灌胃给药，从交配前两周持续到 GD8。平行组还接受补充胆碱的饮食。在没有补充胆碱的情况下，EA 诱导早期吸收，仅当通过饮食给予时具有统计学意义。补充胆碱可轻微减轻着床成功率的降低。我们得出结论，只有在交配前开始暴露时，EA 才会影响着床；饮食给药比灌胃给药更有效；并且胆碱稳态的干扰可能在这种病变的发病机制中起作用。
