Department of Plastic and Reconstructive Surgery, Tel-Aviv Sourasky Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Department of Plastic and Reconstructive Surgery, Tel-Aviv Sourasky Medical Center, Affiliated with the Sackler Faculty of Medicine, Tel-Aviv University, Tel-Aviv, Israel.
Breast. 2018 Jun;39:97-100. doi: 10.1016/j.breast.2018.04.006. Epub 2018 Apr 7.
Radiation-induced morphea (RIM) is a rare, painful and disfiguring complication in women who receive adjuvant radiotherapy treatment for breast cancer. It is a distinct entity unrelated to radiation-induced fibrosis of the breast.
Between the years 2005-2016, approximately 12,000 breast cancer cases were treated with surgery and radiation in the central district of Israel. From that population, we have identified and managed the cases of breast RIM by a multidisciplinary team of dermatologists, breast surgeons, and plastic surgeons. Demographic, oncologic, diagnostic and treatment data were collected and reviewed.
Three cases of breast radiation-induced morphea, with an estimated prevalence of 1:3000 cases of post-breast cancer radiation where identified. The first signs of morphea appeared years after the completion of standard RT. Early management leads to superior cosmetic results.
Unfortunately, there are no known predictors for RIM. Early recognition by the oncologist, the breast surgeon or the reconstructive surgeon during follow-up enables expeditious provision of patient reassurance and helps guide potential treatment options.
放射性硬皮病（RIM）是一种罕见的、疼痛的、毁容性并发症，发生于接受乳腺癌辅助放疗治疗的女性。它是一种与乳房放射性纤维化无关的独特实体。
在 2005 年至 2016 年间，以色列中部地区约有 12000 例乳腺癌病例接受了手术和放疗。我们通过皮肤科医生、乳腺外科医生和整形外科医生组成的多学科团队，对这些患者中的乳房 RIM 病例进行了识别和管理。收集并回顾了人口统计学、肿瘤学、诊断和治疗数据。
我们发现了 3 例乳房放射性硬皮病，在接受乳腺癌放疗后，其发病率估计为 1:3000。硬皮病的最初迹象出现在标准放疗完成多年后。早期管理可获得更好的美容效果。
不幸的是，目前还没有 RIM 的已知预测因素。在随访期间，肿瘤学家、乳腺外科医生或重建外科医生的早期识别能够迅速为患者提供保证，并有助于指导潜在的治疗选择。
