Linking inflammation and cancer: the unexpected SYK world.
作者信息
Fueyo Juan, Alonso Marta M, Parker Kerrigan Brittany C, Gomez-Manzano Candelaria
机构信息
Department of Neuro-Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Department of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, Texas.
出版信息
Neuro Oncol. 2018 Apr 9;20(5):582-583. doi: 10.1093/neuonc/noy036.
Abstract
摘要
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Neuro Oncol. 2018 Apr 9;20(5):621-631. doi: 10.1093/neuonc/noy008.
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Syk inhibitors in clinical development for hematological malignancies.用于血液系统恶性肿瘤临床开发的脾酪氨酸激酶抑制剂。
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TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1.TIE2 介导的 H4 酪氨酸磷酸化通过募集 ABL1 调节 DNA 损伤反应。
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Calling in SYK: SYK's dual role as a tumor promoter and tumor suppressor in cancer.召唤脾酪氨酸激酶（SYK）：SYK在癌症中作为肿瘤促进因子和肿瘤抑制因子的双重作用
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EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4.表皮生长因子受体（EGFR）通过组蛋白 H4 的 Tyr 磷酸化调节 DNA 合成和修复。
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Getting Syk: spleen tyrosine kinase as a therapeutic target.靶向 Syk：脾酪氨酸激酶作为治疗靶点。
Trends Pharmacol Sci. 2014 Aug;35(8):414-22. doi: 10.1016/j.tips.2014.05.007. Epub 2014 Jun 26.
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A novel retinoblastoma therapy from genomic and epigenetic analyses.基于基因组和表观遗传学分析的新型视网膜母细胞瘤治疗方法。
Nature. 2012 Jan 11;481(7381):329-34. doi: 10.1038/nature10733.
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Src-family and Syk kinases in activating and inhibitory pathways in innate immune cells: signaling cross talk.Src 家族和 Syk 激酶在固有免疫细胞激活和抑制途径中的作用：信号转导串扰。
Cold Spring Harb Perspect Biol. 2011 Mar 1;3(3):a002352. doi: 10.1101/cshperspect.a002352.
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The SYK tyrosine kinase: a crucial player in diverse biological functions.SYK 酪氨酸激酶：多种生物学功能的关键参与者。
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Syk tyrosine kinase mediates Epstein-Barr virus latent membrane protein 2A-induced cell migration in epithelial cells.Syk酪氨酸激酶介导爱泼斯坦-巴尔病毒潜伏膜蛋白2A诱导的上皮细胞迁移。
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