全基因组重测序揭示了鸭驯化的选择和时间特征。
Whole-genome resequencing reveals signatures of selection and timing of duck domestication.
机构信息
State Key Laboratory of Animal Nutrition, Department of Animal Genetics and Breeding, National Engineering Laboratory for Animal Breeding, College of Animal Science and Technology, China Agricultural University, Beijing, China.
Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing, China.
出版信息
Gigascience. 2018 Apr 1;7(4). doi: 10.1093/gigascience/giy027.
BACKGROUND
The genetic basis of animal domestication remains poorly understood, and systems with substantial phenotypic differences between wild and domestic populations are useful for elucidating the genetic basis of adaptation to new environments as well as the genetic basis of rapid phenotypic change. Here, we sequenced the whole genome of 78 individual ducks, from two wild and seven domesticated populations, with an average sequencing depth of 6.42X per individual.
RESULTS
Our population and demographic analyses indicate a complex history of domestication, with early selection for separate meat and egg lineages. Genomic comparison of wild to domesticated populations suggests that genes that affect brain and neuronal development have undergone strong positive selection during domestication. Our FST analysis also indicates that the duck white plumage is the result of selection at the melanogenesis-associated transcription factor locus.
CONCLUSIONS
Our results advance the understanding of animal domestication and selection for complex phenotypic traits.
背景
动物驯化的遗传基础仍知之甚少，而野生和家养群体之间存在显著表型差异的系统对于阐明适应新环境的遗传基础以及快速表型变化的遗传基础非常有用。在这里，我们对 78 只个体鸭进行了全基因组测序，这些个体鸭来自两个野生种群和七个家养种群，每个个体的平均测序深度为 6.42X。
结果
我们的群体和人口分析表明，驯化的历史非常复杂，早期对肉用和蛋用两个品系进行了选择。野生种群和家养种群的基因组比较表明，影响大脑和神经元发育的基因在驯化过程中经历了强烈的正向选择。我们的 FST 分析还表明，鸭的白色羽毛是黑色素生成相关转录因子基因座选择的结果。
结论
我们的研究结果推进了对动物驯化和复杂表型特征选择的理解。
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