波波罗环酮G - I，来自海洋海绵秀丽指海绵的具有白细胞介素-6抑制活性的二聚倍半萜醌类化合物。

Popolohuanones G - I, Dimeric Sesquiterpene Quinones with IL-6 Inhibitory Activity from the Marine Sponge Dactylospongia elegans.

作者信息

Li Jing, Wu Wei, Yang Fan, Liu Li, Wang Shu-Ping, Jiao Wei-Hua, Xu Shi-Hai, Lin Hou-Wen

机构信息

College of Pharmacy, Jinan University, Guangzhou, 510632, P. R. China.

Research Center for Marine Drugs, State Key Laboratory of Oncogenes and Related Genes, Department of Pharmacy, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, P. R. China.

出版信息

Chem Biodivers. 2018 Jun;15(6):e1800078. doi: 10.1002/cbdv.201800078. Epub 2018 May 23.

DOI:10.1002/cbdv.201800078

PMID:29635790

Abstract

Chemical investigation of the marine sponge Dactylospongia elegans, collected from the South China Sea, afforded three new dimeric sesquiterpene quinones, popolohuanones G - I (1 - 3), together with two known analogs, popolohuanones B (4) and C (5). The new structures were determined by HR-ESI-MS and 1D- and 2D-NMR analyses. All the five compounds showed no cytotoxic activity against five human cancer cell lines, while popolohuanone H (2) showed potent inhibitory activity against IL-6, an inflammatory cytokine, at the concentration of 10 μm.

摘要

对采自中国南海的海洋海绵优雅指海绵（Dactylospongia elegans）进行化学研究，得到了三种新的二聚倍半萜醌类化合物，波波洛环酮G - I（1 - 3），以及两种已知类似物，波波洛环酮B（4）和C（5）。通过高分辨电喷雾电离质谱（HR-ESI-MS）以及一维和二维核磁共振（1D-和2D-NMR）分析确定了新化合物的结构。所有这五种化合物对五种人类癌细胞系均无细胞毒性活性，而波波洛环酮H（2）在浓度为10 μM时对炎症细胞因子白细胞介素-6（IL-6）显示出强效抑制活性。