State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China.
Key Laboratory of Marine Drugs, The Ministry of Education of China, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China.
Mar Drugs. 2022 Feb 1;20(2):118. doi: 10.3390/md20020118.
Four new sesquiterpene hydroquinones, xishaeleganins A-D (-), along with eleven known related ones ( and -) were isolated from the Xisha marine sponge (family Thorectida). Their structures were determined by extensive spectroscopic analysis, ECD calculations, and by comparison with the spectral data reported in the literature. Compounds , , , and showed significant antibacterial activity against , with minimum inhibitory concentration values of 1.5, 2.9, 5.6, and 5.6 µg/mL, which are comparable with those obtained for the positive control vancomycin (MIC: 1.0 µg/mL).
从西沙海域海绵（Thorectida 科）中分离得到了 4 种新的倍半萜氢醌类化合物西沙埃勒苷 A-D（-），以及 11 种已知的相关化合物（-）。通过广泛的光谱分析、ECD 计算以及与文献报道的光谱数据进行比较，确定了它们的结构。化合物 、 、 、和 对 表现出显著的抗菌活性，最小抑菌浓度值分别为 1.5、2.9、5.6 和 5.6 µg/mL，与阳性对照万古霉素（MIC：1.0 µg/mL）相当。
