Department of Chemistry, University of Hawaii at Manoa, Honolulu, HI 96822, USA.
University of Hawaii Cancer Center, Honolulu, HI 96813, USA.
Mar Drugs. 2019 Jul 19;17(7):423. doi: 10.3390/md17070423.
Several known sesquiterpenoid quinones and quinols (-), and kauamide (), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge . The planar structure of was determined from spectroscopic analyses, and its relative and absolute configurations were established from density functional theory (DFT) calculations of the GIAO NMR shielding tensors, and advanced Marfey's analysis of the -MeLeu residue, respectively. Compounds and showed moderate inhibition of β-secretase 1 (BACE1), whereas - exhibited moderate to potent inhibition of growth of human glioma (U251) cells. Compounds - and - were also active against human pancreatic carcinoma (Panc-1) cells.
从夏威夷海洋海绵 中提取到了几种已知的倍半萜类醌和醌醇（-）以及考胺（），这是一种含有 11 元杂环的新型聚酮肽。通过光谱分析确定了 的平面结构，并通过密度泛函理论（DFT）计算 GIAO NMR 屏蔽张量和对 -MeLeu 残基的高级 Marfey 分析分别确定了其相对和绝对构型。化合物 和 对 β-分泌酶 1（BACE1）有中等抑制作用，而 -对人神经胶质瘤（U251）细胞的生长有中等至较强的抑制作用。化合物 - 和 - 对人胰腺癌细胞（Panc-1）也有活性。
