Timóteo R Pessato, Silva A Ferreira, Micheli D Côbo, Candido Murta E F, Freire M, Teodoro R Botelho, Lima F M, Martins Tavares Murta B, Bertoncello D
1 Discipline of Special Pathology, 74348 Universidade Federal do Triangulo Mineiro , Uberaba, Brazil.
2 Department of Applied Physical Therapy, Institute of Health Sciences, 74348 Universidade Federal do Triangulo Mineiro , Uberaba, Brazil.
Lupus. 2018 Jun;27(7):1159-1168. doi: 10.1177/0961203318768880. Epub 2018 Apr 10.
The effect of physical activity on the immune system is still poorly understood in cases of systemic lupus erythematosus (SLE). Therefore, our aim was to investigate differences in the serum levels of cytokines (IL-2, IL-5, IL-6, IL-8, IL-10 and TNF-α) and the numbers of CD11b + and CXCR2 + neutrophils and lymphocytes in women with SLE undergoing drug treatment, without ( n = 9) or with ( n = 5) 4 months of kinesiotherapy. Parameters related to functional capacity were also analyzed. In the case of the patients who were not submitted to kinesiotherapy, there were reductions in the levels of IL-5, IL-6 and IL-10, and an increase in the number of CD11b + leukocytes, in addition to an increase in abdominal circumference after the monitoring time. Patients submitted to kinesiotherapy did not present changes in serum cytokines or in the numbers of CD11b + and CXCR2 + neutrophils and lymphocytes, but there were increases of flexibility and strength, as well as a reduction in pain sensation after the monitoring time. In conclusion, kinesiotherapy was able to increase flexibility and reduce pain in SLE patients without influencing immune parameters.
在系统性红斑狼疮（SLE）病例中，体育活动对免疫系统的影响仍知之甚少。因此，我们的目的是研究接受药物治疗的SLE女性患者在未接受（n = 9）或接受（n = 5）4个月运动疗法的情况下，细胞因子（IL-2、IL-5、IL-6、IL-8、IL-10和TNF-α）血清水平以及CD11b +和CXCR2 +中性粒细胞和淋巴细胞数量的差异。还分析了与功能能力相关的参数。在未接受运动疗法的患者中，监测期后IL-5、IL-6和IL-10水平降低，CD11b +白细胞数量增加，此外腹围增加。接受运动疗法的患者血清细胞因子或CD11b +和CXCR2 +中性粒细胞及淋巴细胞数量没有变化，但监测期后灵活性和力量增加，疼痛感觉减轻。总之，运动疗法能够增加SLE患者的灵活性并减轻疼痛，而不影响免疫参数。
