Sola-Rodríguez Sergio, Gavilán-Carrera Blanca, Vargas-Hitos José Antonio, Sabio José Mario, Morillas-de-Laguno Pablo, Soriano-Maldonado Alberto
Department of Education, Faculty of Education Sciences, University of Almería, Almería 04120, Spain.
Department of Physical Education and Sport, Faculty of Sport Sciences, University of Granada, Granada 18071, Spain.
Medicina (Kaunas). 2019 Feb 21;55(2):57. doi: 10.3390/medicina55020057.
Higher physical fitness is associated with a more favorable weight and body composition in the general population, although this association has not been studied in patients with systemic lupus erythematosus (SLE). The aim of the present study was to examine the association of different components of physical fitness with body composition in women with SLE with mild disease activity. This cross-sectional study included 77 women with SLE (43.2 ± 13.8 years old) and clinical stability during the previous 6 months. Body composition (including body mass index (BMI), fat mass index (FMI), waist circumference, waist-to-height ratio and waist-to-hip ratio) was assessed using a stadiometer, an anthropometric tape, and a bioimpedance device. Physical fitness included cardiorespiratory fitness (Siconolfi step test and 6 min walk test), muscular strength (handgrip strength test as upper body measure and 30 s chair stand as lower body measure), and flexibility (back-scratch test). Participants with a fitness level equal or above the median of the study sample were categorized as "fit" and those below the median were categorized as "unfit". Linear regression assessed the association of physical fitness with body composition parameters. Cardiorespiratory fitness and upper body muscular strength were negatively associated with BMI, FMI, waist circumference, and waist-to-height ratio (all, < 0.05). Lower body muscular strength and flexibility were negatively related to FMI, waist circumference, waist-to-height ratio, and waist-to-hip ratio (all, < 0.05). These relationships were still significant after controlling for age, disease duration, accrual damage, and SLE activity. Overall, fit patients presented significantly lower values in all body composition parameters compared to unfit patients (all, < 0.05). The main findings of the present study suggest that physical fitness is inversely associated with body composition in women with SLE. Given the cross-sectional nature of this study, future clinical trials should study the causal pathways underlying these relationships.
在一般人群中，较高的身体素质与更有利的体重和身体成分相关，尽管这种关联尚未在系统性红斑狼疮（SLE）患者中进行研究。本研究的目的是探讨轻度疾病活动的SLE女性患者身体素质的不同组成部分与身体成分之间的关联。这项横断面研究纳入了77名SLE女性患者（年龄43.2±13.8岁），且在过去6个月内病情临床稳定。使用身高计、人体测量带和生物电阻抗设备评估身体成分（包括体重指数（BMI）、脂肪量指数（FMI）、腰围、腰高比和腰臀比）。身体素质包括心肺适能（西科诺尔菲台阶试验和6分钟步行试验）、肌肉力量（握力测试作为上半身测量指标，30秒坐立试验作为下半身测量指标）和柔韧性（背部抓挠试验）。身体素质水平等于或高于研究样本中位数的参与者被归类为“健康”，低于中位数的参与者被归类为“不健康”。线性回归评估身体素质与身体成分参数之间的关联。心肺适能和上半身肌肉力量与BMI、FMI、腰围和腰高比呈负相关（均P<0.05）。下半身肌肉力量和柔韧性与FMI、腰围、腰高比和腰臀比呈负相关（均P<0.05）。在控制年龄、病程、累积损伤和SLE活动后，这些关系仍然显著。总体而言，与不健康的患者相比，健康患者在所有身体成分参数上的值均显著更低（均P<0.05）。本研究的主要发现表明，SLE女性患者的身体素质与身体成分呈负相关。鉴于本研究的横断面性质，未来的临床试验应研究这些关系背后的因果途径。
