HIV-1 RNA基因组中的多嘌呤序列变化如何导致对整合酶抑制剂多替拉韦产生耐药性。 - Suppr

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超能文献

How Polypurine Tract Changes in the HIV-1 RNA Genome Can Cause Resistance against the Integrase Inhibitor Dolutegravir.

作者信息

Das Atze T, Berkhout Ben

机构信息

Laboratory of Experimental Virology, University of Amsterdam, Amsterdam, The Netherlands.

Laboratory of Experimental Virology, University of Amsterdam, Amsterdam, The Netherlands

出版信息

mBio. 2018 Apr 10;9(2):e00006-18. doi: 10.1128/mBio.00006-18.

DOI:10.1128/mBio.00006-18

PMID:29636435

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5893875/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9ecc/5893875/80c5a5cac6a3/mbo0021838370001.jpg

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本文引用的文献

Mutations Located outside the Integrase Gene Can Confer Resistance to HIV-1 Integrase Strand Transfer Inhibitors.突变位于整合酶基因之外可赋予 HIV-1 整合酶链转移抑制剂耐药性。

mBio. 2017 Sep 26;8(5):e00922-17. doi: 10.1128/mBio.00922-17.

Retroviral intasomes arising.逆转录病毒内切体的出现。

Curr Opin Struct Biol. 2017 Dec;47:23-29. doi: 10.1016/j.sbi.2017.04.005. Epub 2017 Apr 28.

A supramolecular assembly mediates lentiviral DNA integration.一种超分子组装介导慢病毒DNA整合。

Science. 2017 Jan 6;355(6320):93-95. doi: 10.1126/science.aah7002.

Retroviral DNA Integration.逆转录病毒DNA整合

Chem Rev. 2016 Oct 26;116(20):12730-12757. doi: 10.1021/acs.chemrev.6b00125. Epub 2016 May 20.

Structural basis for retroviral integration into nucleosomes.逆转录病毒整合入核小体的结构基础。

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Dolutegravir interactions with HIV-1 integrase-DNA: structural rationale for drug resistance and dissociation kinetics.多替拉韦与 HIV-1 整合酶-DNA 的相互作用：耐药性和离解动力学的结构原理。

PLoS One. 2013 Oct 16;8(10):e77448. doi: 10.1371/journal.pone.0077448. eCollection 2013.

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Mutations in the RNase H domain of HIV-1 reverse transcriptase affect the initiation of DNA synthesis and the specificity of RNase H cleavage in vivo.HIV-1逆转录酶核糖核酸酶H结构域的突变会影响体内DNA合成的起始以及核糖核酸酶H切割的特异性。

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